Beta-cyclodextrin/magnetic nanoparticle/Go electrochemical sensor

A technology of magnetic nanoparticles and cyclodextrin, applied in the direction of material electrochemical variables, scientific instruments, nanotechnology, etc., can solve the problem of high manufacturing cost, and achieve the effect of fast electron transfer, strong catalytic ability, and good dispersion

Pending Publication Date: 2020-11-17
ZUNYI NORMAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the presence of a large amount of ascorbic acid, the electrode can selectively and simultaneously measure the neurotransmitters 5-HT and dopamine, and the potential difference reaches 220mV, forming a new detection method; but the cost of making this scheme is high

Method used

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  • Beta-cyclodextrin/magnetic nanoparticle/Go electrochemical sensor
  • Beta-cyclodextrin/magnetic nanoparticle/Go electrochemical sensor
  • Beta-cyclodextrin/magnetic nanoparticle/Go electrochemical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A kind of β-cyclodextrin / magnetic nanoparticles (Fe 3 o 4 -MnO 2 ) / graphene oxide (GO) electrochemical sensor, its manufacture method comprises the steps:

[0036] 1) Preparation of magnetic nanoparticles / GO composites

[0037] Add FeSO to 30 mL of graphene oxide solution with a concentration of 0.3 mg / mL 4 ·7H 2 O 0.3g, stirred to dissolve, heated in a water bath to 80°C, added 5mL of 2mol / L NaOH solution under the protection of an inert atmosphere, a yellow-green precipitate appeared in the solution, and the concentration was 0.1mol / L KMnO 4 Add 0.8mL of the solution to the above solution, the solution turns from yellow-green to brown, keep warm for 3 hours, centrifuge and wash until neutral, and vacuum dry at 50°C for later use;

[0038] 2) Preparation of β-cyclodextrin / magnetic nanoparticles / GO composites

[0039] Weigh 0.1 g of the magnetic nanoparticle / graphene oxide composite material obtained in step (1) into 40 mL of water, add 0.1 g of β-cyclodextrin, re...

Embodiment 2

[0043] A kind of β-cyclodextrin / magnetic nanoparticles / GO composite material, its preparation method is:

[0044] 1) Preparation of magnetic nanoparticles / GO composites

[0045]Take 20 mL of graphene oxide solution with a concentration of 0.2 mg / mL, add 0.2 g of ferrous sulfate heptahydrate, stir to fully dissolve ferrous sulfate heptahydrate, heat in a water bath to 70 °C, and add 2 mol / L hydrogen under the protection of an inert atmosphere Sodium oxide 2mL, when the yellow-green precipitate appears, add 0.4mL of potassium permanganate solution to it, wait for the yellow-green precipitate to turn into a brown solution, keep warm for 2h, centrifuge and wash until neutral, and dry in vacuum at 50°C;

[0046] 2) Preparation of β-cyclodextrin / magnetic nanoparticles / GO composites

[0047] Weigh 0.1 g of the magnetic nanoparticle / GO composite material obtained in step (1) into 40 mL of water, add 0.1 g of β-cyclodextrin, react in a constant temperature water bath at 58 °C for 4 h,...

Embodiment 3

[0049] A kind of β-cyclodextrin / magnetic nanoparticles / GO composite material, its preparation method is:

[0050] 1) Preparation of magnetic nanoparticles / GO composites

[0051] Take 50 mL of graphene oxide solution with a concentration of 0.5 mg / mL, add 1.0 g of ferrous sulfate heptahydrate, stir to fully dissolve ferrous sulfate heptahydrate, heat in a water bath to 90°C, and add 2 mol / L hydrogen under the protection of an inert atmosphere Sodium oxide 10mL, when the yellow-green precipitate appears, add 0.8mL of potassium permanganate solution to it, wait for the yellow-green precipitate to turn into a brown solution, keep it warm for 4 hours, centrifuge and wash until neutral, and dry it under vacuum at 50°C;

[0052] 2) Preparation of β-cyclodextrin / magnetic nanoparticles / GO composites

[0053] Weigh 0.2 g of the magnetic nanoparticle / GO composite material obtained in step (1) into 40 mL of water, add 0.2 g of β-cyclodextrin, react in a constant temperature water bath at...

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Abstract

The invention belongs to the technical field of electrochemical sensor preparation, and particularly relates to a beta-cyclodextrin / magnetic nanoparticle / GO electrochemical sensor, which is prepared by adhering a beta-cyclodextrin / magnetic nanoparticle / GO composite material to an electrode plate to prepare a modified electrode, and taking the modified electrode as a working electrode, a saturatedcalomel electrode as a reference electrode and a platinum sheet electrode as an auxiliary electrode to form an electrochemical sensor whch is used for detecting the content of serotonin; The beta cyclodextrin / magnetic nanoparticle / GO electrochemical sensor prepared by the method has the characteristics of large specific surface area, fast electron transfer, strong catalytic ability, good dispersibility and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation of electrochemical sensors, in particular to a β-cyclodextrin / magnetic nanoparticle / GO electrochemical sensor. Background technique [0002] 5-Hydroxytryptamine is a very important neurotransmitter of the central nervous system, which widely exists in mammals and has a regulatory effect on all aspects of the human body, especially in the regulation of cardiovascular and cerebrovascular, and studies have shown that 5-hydroxytryptamine in the central nervous system Abnormal levels of serotonin are closely related to depression and other diseases. Therefore, measuring the content of 5-hydroxytryptamine in blood and cerebrospinal fluid can provide scientific basis for the diagnosis and treatment of diseases. [0003] At present, the determination of 5-hydroxytryptamine mainly adopts high performance liquid chromatography, immunoassay, fluorescence method and so on. However, these methods usually...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N27/48B82Y40/00B82Y15/00
CPCG01N27/3277G01N27/48B82Y15/00B82Y40/00
Inventor 牟青松罗宿星伍远辉
Owner ZUNYI NORMAL COLLEGE
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