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Method inducing satiety in a mammal

A mammalian and satiety technology, which is applied in the field of treating or preventing obesity in mammals, especially obese mammals, and regulating the food intake of mammals, especially obese mammals, and can solve problems such as weakening transport and the like

Active Publication Date: 2020-12-04
蒂加斯克-农业与食品发展部
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been hypothesized that food processing may impair Fabuless's ability to transport undigested fat to the distal small intestine

Method used

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  • Method inducing satiety in a mammal
  • Method inducing satiety in a mammal
  • Method inducing satiety in a mammal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Materials and methods

[0101] The study was approved by the Medical Ethics Committee and was performed in full compliance with the principles of the 1975 Declaration of Helsinki (revised 2013) and with approval from the Irish and European Medical Research Councils. All participants gave written informed consent before participation. The test has been performed as needed in www.cparticlinicaltrials.gov Register on .

[0102] participant

[0103] Two studies were conducted according to the details below. Efficacy analyzes were performed recruiting eight healthy volunteers for the first study and 72 healthy volunteers for the second study. Recruit volunteers through local advertising and place posters outlining the research program with contact details in public places such as hospital waiting rooms. Social media sites such as Twitter are also used for advertising. Advertisements contain only necessary information relevant to the research and ethics committee-app...

Embodiment 2

[0177] When a dose of encapsulated lipid prepared according to the method described in Example 1 but containing 500 Kcal of lipid was delivered to the ileum by the oral route, 8 of 9 subjects were ingesting lipid 60-120 Minutes later, strong bowel movements began. Without being bound by theory, it is believed that due to lack of bile in the ileum, lipids are not absorbed in the ileum, thus triggering strong bowel movements. Bile secretion is usually triggered by the presence of lipids in the stomach. Using the methods of the present invention, the subject's bile secretion was not initiated because the lipid was not released in the stomach, resulting in a lack of bile in the ileum when the lipid was released.

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Abstract

A therapeutic or non-therapeutic method of inducing satiety in a mammal is described. The method comprises administering to the mammal a composition comprising microparticles, in which the microparticles comprise lipid contained within a gastric-resistant, ileal-sensitive, carrier configured for release of the lipid in the ileum, wherein the composition is administered 1-3 hours prior to a meal. The carrier is a protein, typically denatured or hydrolysed plant or dairy protein, that is polymerised to form a lipid containing shell or matrix.

Description

technical field [0001] The present invention relates to methods of inducing satiety in mammals. The present invention also relates to methods of modulating food intake in mammals, especially obese mammals. The invention also relates to methods of treating or preventing obesity in mammals, especially obese mammals. Background technique [0002] Worldwide, the rapidly rising prevalence of overweight and obesity has prompted research into foods or food products that have therapeutic potential in the management of overweight, obesity and related diseases. For example, so-called functional foods contain nutrients that lead to a greater reduction in food intake than would be expected based on their caloric content alone. These functional foods may play a role in dieting programs to improve adherence by reducing hunger between meals, producing gut peptide hormone responses, delaying subsequent meal sizes, and reducing caloric intake. Recent studies have shown that, under normal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A23P10/30A61P1/00
CPCA61K9/5052A23P10/30A61P1/00A61K31/202A61P3/04A23L33/19A23L33/115A23P10/35A23L33/185A23L33/40A23L2/66A23V2002/00A61K9/0053A61K9/4808A61K9/5089
Inventor 西奈德·布莱尔罗伯特·肯特尼尔·杰拉德·多彻蒂卡雷尔·韦纳德·勒鲁
Owner 蒂加斯克-农业与食品发展部