Prediction system for predicting occurrence of calcium oxalate kidney stone

A prediction system and technology for kidney stones, applied in the field of neural network, can solve the problems of calcium oxalate kidney stone prediction system, etc., and achieve the effect of accurate prediction effect.

Active Publication Date: 2020-12-08
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology uses three different types of data from medical tests or biological samples collected during an examination process to make predictions about how likely they are getting stuck with certain diseases such as renal calculi. Random-forest models have been shown to outperform traditional methods by providing more precise results than other techniques like machine learning.

Problems solved by technology

This patented problem addressed in this patents relates to finding ways to reduce damage from excessively high levels of certain compounds found within renal calculus called calcified materials during medical procedures such as lithotripsy surgery. Current techniques involve measuring these deposits through histopathology analysis but they cannot accurately determine if any new ones occur without subjecting subjects who may already suffer harm due to their symptoms.

Method used

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  • Prediction system for predicting occurrence of calcium oxalate kidney stone
  • Prediction system for predicting occurrence of calcium oxalate kidney stone

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Embodiment 1

[0036]Example 1. The prediction method of the present invention for predicting the occurrence of calcium oxalate kidney stones

[0037]The present invention combines 3 clinical indexes and 4 bacterial genus indexes to establish a prediction model to predict the occurrence of calcium oxalate kidney stones.

[0038]The three clinical indicators are: gender, oxalic acid concentration in urine and acetic acid concentration in feces;

[0039]The 4 genus indicators are:

[0040]g__Geobacter_f__Geobacteraceae_o__Desulfuromonadales_c__Deltaproteobacteria_p__Proteobacteria (abbreviated as g__Geobacter) relative abundance value,

[0041]relative abundance value of g__Kroppenstedtia_f__Thermoactinomycetaceae_o__Bacillales_c__Bacilli_p__Firmicutes (abbreviated as g__Kroppenstedtia),

[0042]g__Sphaerochaeta_f__Spirochaetaceae_o__Spirochaetales_c__Spirochaetia_p__Spirochaetes (abbreviated as g__Sphaerochaeta) relative abundance value,

[0043]The relative abundance value of g__Oscillospira_f__Ruminococcaceae_o__Clos...

Embodiment 2

[0051]Example 2: Using random forest model to predict the occurrence of calcium oxalate kidney stones

[0052]Call the randomforest package and use the presence or absence of kidney stones in 123 samples (57 cases of kidney stone patients and 66 cases of healthy people) as the category label, and use 5-fold cross-validation to divide the 123 samples into 5 subsets, and randomly select 1 subset as Test, the remaining 4 as training. Enter the Y value and gender of the 4 subsets, the concentration of oxalic acid in urine, the concentration of acetic acid in feces, and the relative abundance values ​​of g__Geobacter, g__Kroppenstedtia, g__Sphaerochaeta and g__Oscillospira, call the randomForest() function, and use the default parameter ntree=500, importance =FALSE, localImp=FALSE, nPerm=1, replace=TRUE, oob.prox=proximity, norm.votes=TRUE, do.trace=FALSE, build a random forest model. Enter the gender of a subset, the concentration of oxalic acid in urine, the concentration of acetic acid i...

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Abstract

The invention provides a prediction system for predicting occurrence of calcium oxalate kidney stone, and belongs to the field of neural networks. The prediction system comprises an input module, a calculation module and an output module. I, the input module is used for transmitting the following information of a patient to the calculation module: gender, oxalic acid concentration in urine, aceticacid concentration in excrement, relative abundance value of g_Geobacter, relative abundance value of g_Kroppenstedtia, relative abundance value of g_Spharochaeta and relative abundance value of g_Oscillospira; II, a trained prediction network model for predicting the occurrence of calcium oxalate kidney stone is built in the calculation module; and III, the output module is used for outputting the probability value Y. Three clinical indexes and relative abundance values of four bacteria genus are combined, and a conventional algorithm is used, so that the occurrence of the kidney stone can be accurately predicted. The prediction effect of a random forest algorithm is the most accurate. The prediction method provided by the invention can accurately predict the kidney stone, especially calcium oxalate kidney stone, and can provide a basis for clinical diagnosis and treatment of kidney stone.

Description

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Claims

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Application Information

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Owner WEST CHINA HOSPITAL SICHUAN UNIV
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