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Application of caffeol in hair loss prevention and hair growth

A kind of kahweol, hair loss technology, applied in the fields of compounds and preparations, medicines, can solve the problems such as no literature publicly reported kahweol and the like

Inactive Publication Date: 2020-12-11
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Caffeine alcohol (kahweol), a natural diterpene extracted from coffee beans, mainly exists in unfiltered coffee in the form of fatty esters, has the ability to improve serum lipids, anti-inflammatory, anti-cancer and potential anti-diabetes , but so far there is no public report on the application of kahweol in hair loss and hair growth

Method used

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  • Application of caffeol in hair loss prevention and hair growth
  • Application of caffeol in hair loss prevention and hair growth
  • Application of caffeol in hair loss prevention and hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Curative effect evaluation experiment of kahweol on natural hair growth model of C57BL / 6 mice

[0037] 1. Experimental animals

[0038] The experimental animals were male C57BL / J6, 8 weeks old, weighing 18-20 g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0039] 2. Drug configuration

[0040] 4% chloral hydrate: 0.4g of chloral hydrate was dissolved in 10ml of normal saline, vortex centrifuged until completely dissolved, and prepared into 4% chloral hydrate solution.

[0041] 2.1 2.5% (O / W) kahweol cream for external use, made from the following raw materials:

[0042] 250 parts by weight of cafestol, 1000 parts by weight of stearic acid, 200 pa...

Embodiment 2

[0056] Example 2: Curative effect evaluation experiment of kahweol on C57BL / 6 mouse chemotherapy hair loss model

[0057] 1. Experimental animals

[0058] The experimental animals were male C57BL / J6, 8 weeks old, weighing 18-20 g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0059] 2. Drug configuration

[0060] The configuration of 4% chloral hydrate is the same as above.

[0061] The coffee bean alcohol ointment configuration is the same as above.

[0062] The configuration of kahweol oral suspension is the same as above.

[0063] Cyclophosphamide for injection: Dissolve 0.2g cyclophosphamide in 20ml normal saline, vortex centrifuge until completely dissolved, ...

Embodiment 3

[0076] Example 3: Curative effect evaluation experiment of kahweol on C57BL / 6 mouse androgenetic alopecia model

[0077] 1. Experimental animals

[0078] The experimental animal is C57BL / J6, 8 weeks old, weighing 18-20g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0079] 2. Drug configuration

[0080] The configuration of 4% chloral hydrate is the same as above.

[0081] The coffee bean alcohol ointment configuration is the same as above.

[0082] The configuration of kahweol oral suspension is the same as above.

[0083] Testosterone propionate injection (1mL: 25mg, Guangzhou Baiyunshan Mingxing Pharmaceutical Co., Ltd.), diluted with edible oil to 1mg / ml. The...

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PUM

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Abstract

The invention provides an application of caffeol and physiologically acceptable salts or solvates thereof in the preparation of a skin application composition, and a further application of the skin application composition in medicinal preparations, cosmetics, nursing products and beauty products. The skin application composition and the further applied preparation can comprehensively and effectively aim at various reasons of hair loss, so the skin application composition and the further applied preparation are helpful for balancing the metabolism status of a demand object and adjusting the mental state of the demand object in order to realize good treatment and nursing synergism; and the active component of caffeol has high safety and small toxic and side effects, so the skin application composition and the further applied preparation have wide application prospect in the fields of medicinal preparations, cosmetics, nursing products and beauty products.

Description

technical field [0001] The invention belongs to the field of compounds and preparations thereof, and specifically relates to the use of kahweol in the preparation of anti-hair loss and hair growth preparations, and its further application in the fields of medicine, cosmetics, care products, beauty products and the like. Background technique [0002] Alopecia is the phenomenon of hair falling out. Normal people are also accompanied by hair loss and regeneration in the process of metabolism, which belongs to the normal metabolic phenomenon of biology. The hair that falls out normally is the hair in the catagen and telogen phase. Since the hair entering the catagen and the newly entering the growth phase are constantly in a dynamic balance, it can maintain a normal amount of hair. Pathological hair loss is the phenomenon of abnormal hair loss caused by various reasons, such as excessive stress, staying up late, or endocrine disorders. [0003] Alopecia can be divided into men...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P17/00A61P17/14A61P17/08A61P17/10A61K8/63A61Q7/00A61Q5/00
CPCA61K8/63A61K31/58A61Q5/002A61Q7/00A61P17/00A61P17/08A61P17/10A61P17/14
Inventor 吴亮吴舒婷冯陈杰蔡磊蔡溪云弋董昊郝园园陈佳敏刘宙刘玉琳朱俊霖徐佳怡曹毅眀吴晓明
Owner CHINA PHARM UNIV
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