Ganoderma applanatum composition for enhancing immune function and preparation method thereof

A technology for enhancing immunity and composition, applied in the field of traditional Chinese medicine, can solve problems such as large toxic and side effects of chemicals, and achieve the effects of solving large toxic and side effects, enhancing human immunity, and promoting metabolism

Inactive Publication Date: 2020-12-15
HARBIN PHARMA GROUP TECH CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solved the problem of high toxicity of immunity-enhancing chemicals

Method used

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  • Ganoderma applanatum composition for enhancing immune function and preparation method thereof
  • Ganoderma applanatum composition for enhancing immune function and preparation method thereof
  • Ganoderma applanatum composition for enhancing immune function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The immune-enhancing tongue complex of this embodiment is composed of 3 parts of tree tongue extract, 3 parts of seabuckthorn extract and 2 parts of garlic extract in parts by weight.

[0024] Described tree tongue extract is to make according to the following method:

[0025] Dried the fruiting bodies of the tongue at 70°C for 4 hours, crushed, passed through a 40-mesh sieve, extracted 3 times with 3 times the amount of ethanol (95% concentration) at 75°C for 2 hours each time, combined the filtrates, and distilled under reduced pressure Concentrate to a specific gravity of 1.08-1.12, and dry to obtain the alcohol extract; use water at 70°C as a solvent to extract the residue of the tree tongue after alcohol extraction for 2 hours, filter under reduced pressure to separate the filter residue and filtrate, repeat the same conditions three times, combine the filtrate, and reduce pressure Concentrate to a specific gravity of 1.08 to 1.12, and obtain a water extract after ...

Embodiment 2

[0039] Example 2 Enhanced immune function experiment

[0040] Seventy-five Kunming mice, half male and half female, weighing 18-22 g, were randomly divided into groups A, B, C, D and E. Introduce tumor-bearing mice for ascites passage, select tumor strains with good growth in 7-10 days, aseptically collect ascites, dilute and inoculate under the right axilla of mice. Intramuscular injection was started 6 days after inoculation.

[0041] Group A was the blank control group, and received normal saline. The administration of group B is 50 mg / kg / d of the preparation in the above examples. Group C was given polyporus polysaccharide 50 mg / kg / d. The administration of group D is the composition of the extract of the tree tongue and the extract of Hippophae rhamnoides in the above examples. The administration of group E is the composition of the tree tongue extract and the garlic extract in the above examples. Continuous administration for 10 days, once a day. The mice were sacri...

Embodiment 3

[0044] Example 3 Enhanced immune function experiment

[0045] 45 Kunming mice, half male and half female, weighing 18-22 g, were randomly divided into group A, group B and group C. Group A was the blank control group, and received normal saline. The administration of group B is 50 mg / kg / d of the preparation in the above examples. Group C was given polyporus polysaccharide 50 mg / kg / d. After continuous gavage to the mice for 30 days, the visceral body ratio, serum hemolysin and antibody-producing cells, delayed-type hypersensitivity, NK cell activity, and monocyte-macrophage were measured.

[0046] Results: (1) After 30 days of administration, the thymus index of the mice was significantly increased, which was 0.20±0.02 in group A, 0.28±0.01 in group B, and 0.24±0.04 in group C. (2) After 30 days of administration, the anti-volume number of the mice was significantly increased, which was 115.7±11.5 in group A, 172.6±26.1 in group B, and 157.8±21.2 in group C. At the same tim...

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Abstract

The invention discloses a ganoderma applanatum composition for enhancing immune function and a preparation method thereof, relates to the field of traditional Chinese medicine, provides a method for refining and fully utilizing traditional Chinese medicine resources and provides the composition for enhancing the immune function and a preparation method and application of the composition to overcome the defects in the prior art. Therefore, the utilization rate and the economic value of the ganoderma applanatum, the hippophae rhamnoides and the garlic are improved. Polysaccharide in the ganoderma applanatum extract, flavone in the hippophae rhamnoides extract and allicin in the garlic extract achieve a synergistic effect and jointly achieve the effect of enhancing the human immunity. The three articles are both food and medicine, and are safe and effective to use. And the problem of great toxic and side effects of chemical medicines for enhancing immunity is solved. The composition is applied to the field of medicine preparation.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a tree tongue composition for enhancing immune function and a preparation method thereof. Background technique [0002] Tree tongue, also known as red old mother fungus, flat sesame. It is the fruiting body of Ganoderma lucidum, a fungus of Polyporaceae. Widely planted and distributed throughout the country. Taste slightly bitter, flat in nature. Return spleen, stomach warp. It has the effect of anti-inflammatory and anti-cancer. For pharyngitis, esophageal cancer, nasopharyngeal cancer. It has the pharmacological effects of regulating immune function, anti-tumor, antibacterial and regulating blood pressure. [0003] Seabuckthorn is the fruit of the plant Hippophae rhamnoides in the genus Hippophae, also known as vinegar willow fruit and sour thorn fruit. Sea buckthorn fruit is a small berry plant, deciduous shrub or small tree. Seabuckthorn has hig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61P37/04A23L33/105A23L31/00
CPCA23V2002/00A61K36/074A61K36/185A61K36/8962A61K2236/331A61K2236/333A61K2236/37A61K2236/39A23L31/00A23L33/105A61P37/04A61K2300/00A23V2200/324A23V2250/208A23V2250/21A23V2250/212A23V2300/14A23V2300/38
Inventor 王丽娜杨新春张道旭尹涛王慧一白丽崔琳王晓颖
Owner HARBIN PHARMA GROUP TECH CENT
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