A hydrogen storage nano-palladium photothermal effect targeted release liposome functional group and its preparation method and application

A photothermal effect and nano-palladium technology, applied in the field of biomedicine, can solve the problems of limited repair effect of pigment epithelium, lack of targeted drug effect release, and poor curative effect, so as to achieve anti-oxidation therapy and reduce irreversible thermal damage , High light-to-heat conversion efficiency

Active Publication Date: 2021-08-13
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, PRP has limited effect on the repair of degenerated pigment epithelium
At present, oral adjuvant therapy with reducing antioxidants such as vitamin E, folic acid, venorutone, rutin, zinc, and magnesium is mainly used in clinical practice, but the curative effect is not good due to the lack of targeted drug release

Method used

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  • A hydrogen storage nano-palladium photothermal effect targeted release liposome functional group and its preparation method and application
  • A hydrogen storage nano-palladium photothermal effect targeted release liposome functional group and its preparation method and application
  • A hydrogen storage nano-palladium photothermal effect targeted release liposome functional group and its preparation method and application

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preparation example Construction

[0042] see figure 1 and figure 2 , a preparation method of hydrogen storage nano-palladium photothermal effect targeted release hydrogen liposome functional group of the present invention, comprising the following steps:

[0043] S1, preparing nano-palladium particles;

[0044] S101. Under the condition of magnetic stirring at 80-85 degrees Celsius, mix PVP (104-108mg), L-ascorbicacid (58-64mg), KBr (290-310mg) and Na 2 PdCl 4 (55~57mg) in aqueous solution (10~12ml) was heated for 3~4 hours, then cooled to room temperature;

[0045] S102, after centrifugation for 30-35min, after washing 2-4 times, collect and purify nano-palladium crystals with an Amicon filter tube (molecular weight cut-off 100kDa);

[0046] S103. Disperse the obtained nano-palladium crystals in 9-12 mL of deionized water, and store in dark conditions for subsequent use.

[0047] S2, preparing hydrogen storage nano-palladium particles;

[0048] S201. Inject 2-4ml of nano-palladium crystals into a 20mL vi...

Embodiment 1

[0060] Under magnetic stirring conditions at 80 degrees Celsius, PVP (104mg), L-ascorbic acid (58mg), KBr (290mg) and Na 2 PdCl 4 (55mg) in water (10ml) was heated for 3 hours, then cooled to room temperature;

[0061] After centrifugation for 30min, after washing twice, collect and purify nano palladium crystals with Amicon filter tube;

[0062] The obtained nano-palladium crystals were dispersed in 9 mL of deionized water and stored under dark conditions for subsequent use.

[0063] Inject 2ml of nano-palladium crystals into a 20mL vial sealed with a rubber stopper, and then add 90mg of NaBH 4 Put into another vial sealed with a rubber stopper; connect the two vials with a capillary, insert a needle into the first vial with a 1 ml syringe to connect to the atmosphere; then inject 2 mL of pH=5 Sulfuric acid solution injection containing NaBH 4 in the second vial; in the presence of acidic solution, NaBH 4 Can generate hydrogen, so that hydrogen can slowly enter the nano-...

Embodiment 2

[0067] Under the condition of magnetic stirring at 80 degrees Celsius, PVP (105mg), L-ascorbic acid (60mg), KBr (300mg) and Na 2 PdCl 4 (56mg) in water (11ml) was heated for 3.5 hours, then cooled to room temperature;

[0068] After centrifugation for 32min, after washing 3 times, collect and purify nano palladium crystals with Amicon filter tube;

[0069] The obtained nano-palladium crystals were dispersed in 10 mL of deionized water and stored under dark conditions for subsequent use.

[0070] Inject 3ml of nano-palladium crystals into a 20mL vial sealed with a rubber stopper, and then add 95mg of NaBH 4 Put into another vial sealed with a rubber stopper; connect the two vials with a capillary, insert a needle into the first vial with a 1 ml syringe to connect to the atmosphere; then inject 2 mL of pH=5 Sulfuric acid solution injection containing NaBH 4 in the second vial; in the presence of acidic solution, NaBH 4 Can generate hydrogen, so that hydrogen can slowly ente...

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Abstract

The invention discloses a hydrogen storage nano palladium photothermal effect targeted release liposome functional group and its preparation method and application, comprising polymer modified liposomes, hydrogen storage nano palladium particles, the hydrogen storage nano palladium particles are arranged on the liposome plastid. The invention effectively combines the photothermal effect and hemodynamic response, and the hydrogen gas generated by the hydrogen storage nano-palladium particles effectively reduces the active oxygen level of cells to realize anti-oxidation treatment; at the same time, the local photothermal effect promotes the polymerization of liposomes with a diameter of 90-240 μm The vesicles can effectively block the blood vessels, and use the physical characteristics of the lipid membrane to realize the targeted release and retention of hydrogen gas, accelerate the formation of thrombus, and ensure the complete blockage of blood vessels.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a hydrogen storage nano-palladium photothermal effect targeted release liposome functional group and its preparation method and application. Background technique [0002] Eyes are the most important sensory organs of human beings. Fundus disease is a general term for a series of eye diseases that occur in the fundus, including diabetic retinopathy, central retinal vein occlusion, and age-related macular degeneration. It mostly occurs in the elderly people with diabetes and high blood pressure. The etiology is mainly due to the damage and rupture of retinal capillaries in a high-sugar and high-pressure environment for a long time, resulting in exudate. Due to the degeneration of the retinal pigment epithelium due to age, complications and other reasons, it is impossible to metabolize and discharge the exudate, causing it to accumulate in the center of the macula, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K47/24A61K41/00A61K33/00A61P27/02A61P9/14
CPCA61K9/127A61K33/00A61K41/0042A61K41/0052A61K47/24A61P9/14A61P27/02A61K2300/00
Inventor 李东赵鹏辉陈斌
Owner XI AN JIAOTONG UNIV
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