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Application of endometriosis serum marker

A technology of serum markers and endometrium, which is applied in the field of application of serum markers of endometriosis, can solve the problems of affecting diagnostic accuracy, not showing correlation, screening sensitivity, and specificity decline

Active Publication Date: 2021-01-05
AFFILIATED HOSPITAL OF JIANGNAN UNIV
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  • Claims
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AI Technical Summary

Problems solved by technology

However, since CA125 and CA199 are significantly elevated in ovarian cancer patients, the sensitivity and specificity of screening will decrease.
Moreover, in the treatment of endometriosis, the expression of CA125 did not show a correlation with the decline, which not only affects the accuracy of diagnosis, but also has obvious defects as a monitoring index of curative effect

Method used

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  • Application of endometriosis serum marker
  • Application of endometriosis serum marker
  • Application of endometriosis serum marker

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Experimental program
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Effect test

Embodiment 1

[0017] 1. Candidate gene identification

[0018] Data processing Gene expression microarray datasets were processed with R language. In GSE25628, analysis was performed with the limma package (3.32.10) in R language. The differential gene for GSE25628 was identified in 8 ectopic and 8 eutopic endometrial samples. The result is as figure 1 shown.

[0019] 2. Serum protein detection

[0020] In 142 patients with endometriosis, 62 patients with non-endometriosis and 39 patients with ovarian cancer, the screened angiotensinogen (AGT) and sclerostin domain protein 1 (SOSTDC1) Serum protein detection was performed.

[0021] The basic clinical information of the patient is as follows:

[0022]

[0023]

[0024] In the table: r-AFS, American Fertility Society classification (revised); BMI, body mass index; NA, missing value.

[0025] 2.1 Detection principle

[0026] Double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) was used. Add samples, standards, and ...

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Abstract

The invention discloses application of an endometriosis serum marker in preparation of endometriosis screening and diagnosis products, and belongs to the technical field of biological medicines. The endometriosis serum marker is angiotensinogen (AGT) and / or sclerostin domain protein 1 (SOSTDC1). When AGT and SOSTDC1 are used as target spots for respectively detecting serum protein, the sensitivityand specificity are high, so that AGT and SOSTDC1 can be used as screening target spots for endometriosis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of a group of endometriosis serum markers. Background technique [0002] Endometriosis is a benign gynecological disorder in which endometrial tissue grows outside the uterine cavity. Usually endometriotic tissue implants in the ovaries and pelvis, but endometriotic tissue has also been found in the liver, lower extremities, brain, and pleura. In addition, endometriosis resembles malignancy, such as invasive growth, progressive metastasis. Currently, a large number of deregulated genes have been identified in endometriotic cells, whose functions include apoptosis, immune system regulation, angiogenesis, and cell adhesion. Currently, there is still no cure for endometriosis. [0003] The current serum screening for endometriosis mainly uses CA125 and CA199 as the main detection targets. However, since CA125 and CA199 are significantly elevated i...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/364G01N2333/575G01N2333/47
Inventor 全超边泽华
Owner AFFILIATED HOSPITAL OF JIANGNAN UNIV
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