Application of Serum Markers in Endometriosis

A technology of serum markers and endometrium, which is applied in the application field of serum markers of endometriosis, can solve the problems of screening sensitivity, specificity decline, and curative effect monitoring index defect and increase

Active Publication Date: 2022-07-29
AFFILIATED HOSPITAL OF JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since CA125 and CA199 are significantly elevated in ovarian cancer patients, the sensitivity and specificity of screening will decrease.
Moreover, in the treatment of endometriosis, the expression of CA125 did not show a correlation with the decline, which not only affects the accuracy of diagnosis, but also has obvious defects as a monitoring index of curative effect

Method used

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  • Application of Serum Markers in Endometriosis
  • Application of Serum Markers in Endometriosis
  • Application of Serum Markers in Endometriosis

Examples

Experimental program
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Effect test

Embodiment 1

[0017] 1. Candidate gene identification

[0018] Data processing The gene expression microarray dataset was processed in R language. In GSE25628, the analysis was performed with the limma software package (3.32.10) in the r language. Differential genes for GSE25628 were identified in 8 ectopic and 8 eutopic endometrial samples. The result is as figure 1 shown.

[0019] 2. Serum protein detection

[0020] In 142 endometriosis patients, 62 non-endometriosis patients and 39 ovarian cancer patients, the selected angiotensinogen (AGT) and sclerostin domain protein 1 (SOSTDC1) Serum protein detection was performed.

[0021] The basic clinical information of the patient is as follows:

[0022]

[0023]

[0024] In the table: r-AFS, American Fertility Society classification (revised); BMI, body mass index; NA, missing value.

[0025] 2.1 Detection principle

[0026] Double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). To the coated microwells pre-containi...

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Abstract

The invention discloses the application of endometriosis serum markers in the preparation of endometriosis screening and diagnosis products, belonging to the technical field of biomedicine. The endometriosis serum markers are blood vessels Tensinogen (AGT) and / or sclerostin domain protein 1 (SOSTDC1). When AGT and SOSTDC1 were used as targets for the detection of serum proteins, both had high sensitivity and specificity, so they could be used as screening targets for endometriosis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of a group of endometriosis serum markers. Background technique [0002] Endometriosis is a benign gynecological disorder in which endometrial tissue grows outside the uterine cavity. Usually endometriotic tissue implants in the ovaries and pelvis, but endometriotic tissue is also found in the liver, lower extremities, brain, and pleura. In addition, endometriosis resembles malignancy, such as aggressive growth, progressive metastases. Currently, a large number of deregulated genes have been identified in endometriotic cells with functions including apoptosis, immune system regulation, angiogenesis and cell adhesion. Currently, there is still no cure for endometriosis. [0003] The current serum screening for endometriosis mainly uses CA125 and CA199 as the main detection targets. However, since CA125 and CA199 are significantly increased in ova...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/364G01N2333/575G01N2333/47
Inventor 全超边泽华
Owner AFFILIATED HOSPITAL OF JIANGNAN UNIV
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