Detection method and quality control method of rhodiola rosea wall-broken decoction pieces

A technology of broken wall decoction pieces and detection method, which can be used in measuring devices, instruments, scientific instruments, etc., and can solve the problems that the quality of decoction pieces cannot be well reflected.

Pending Publication Date: 2021-01-12
GUIZHOU GUANGJITANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the quality detection method constructed by this patent still cannot reflect the quality of the decoction pieces well.

Method used

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  • Detection method and quality control method of rhodiola rosea wall-broken decoction pieces
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  • Detection method and quality control method of rhodiola rosea wall-broken decoction pieces

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preparation example Construction

[0048] In exemplary embodiment, the preparation method of Rhodiola rosea decoction pieces (broken wall) of the present invention at least comprises the following steps:

[0049] (1') dry the Rhodiola rosea raw material of pretreatment to below 7wt% of moisture content, obtain the rhodiola rosea after drying;

[0050] (2') the rhodiola after drying is pulverized to 300-800 order, obtains rhodiola broken wall powder;

[0051] (3') Carry out micropowder inclusion granulation with the Rhodiola rosea broken wall powder without adding any adjuvant or additive, to obtain 30-200 mesh Rhodiola rosea broken wall decoction pieces granules.

[0052] Step (1') of the present invention is the step of obtaining dried Rhodiola rosea. Drying can be performed using any known method. In an exemplary embodiment, the drying of the present invention is freeze drying. Rhodiola is rich in polysaccharides, volatile oils and other substances. Freeze-drying technology is suitable for retaining these ...

Embodiment 1

[0082] 1. The main preparation process of rhodiola decoction pieces (broken wall) is as follows:

[0083] 1. Select and remove the non-medicinal parts of the original medicinal materials of Rhodiola rosea;

[0084] 2. Rinse and break: Rinse the selected Rhodiola rosea and break it into small pieces of 10-15cm;

[0085] 3. Drying: Dry Rhodiola rosea until the moisture content of the original medicinal material is 5%-9%;

[0086] 4. Coarse crushing: After the Rhodiola rosea is crushed to 60-100 mesh with a universal machine, it is then ball milled to 100-500 mesh to obtain raw material coarse powder;

[0087] 5. Breaking the wall and crushing: put the Rhodiola rosea coarse powder in the jet mill, the feed pressure is 0.6-0.8MPa, the frequency is 35-45Hz, the induced air pressure difference is 0.2-0.7MPa, and the moisture content of the material is below 7%. 1. Carry out airflow crushing under the condition of 60-100 mesh, and pulverize to 300-800 mesh to obtain Rhodiola rosea ...

Embodiment 2

[0112] This example is a comparative study on the fingerprints of Rhodiola decoction pieces (broken wall) and traditional decoction pieces.

[0113] 10 batches of original samples come from Tibet, Sichuan, Inner Mongolia and other places of origin, and have been identified as Rhodiolacrenulata (Hook.f.et Thoms.) H.Ohba, a plant of Crassulaceae. The traditional decoction pieces are crushed through a No. 3 sieve, and the broken wall decoction pieces are processed and granulated by breaking the wall.

[0114] The chromatographic conditions are: chromatographic column is Agilent C18 column (4.6mm×250mm, 5μm); mobile phase: acetonitrile (A)-0.02% phosphoric acid water (B), gradient elution: 6%A-6%A (0-18min ), 6% A-20% A (18-45min), 20% A-20% A (45-55min), 20% A-22% A (55-65min), 22% A-22% A (65 -90min), DAD detection wavelength 278nm, flow rate 0.8mL min -1 , the column temperature was 30°C, and the injection volume was 10 μL.

[0115] The preparation method of the test sample ...

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Abstract

The invention discloses a detection method and a quality control method of rhodiola rosea wall-broken decoction pieces. The detection method comprises the following steps: (1) acquiring an HPLC (HighPerformance Liquid Chromatography) spectrum of rhodiola rosea decoction pieces (broken walls); (2) confirming the fingerprint information of the obtained HPLC spectrum, wherein the fingerprint information comprises the number of peaks, the relative retention time and the relative peak area; and (3) detecting the quality of the rhodiola rosea decoction pieces (broken walls) based on the fingerprintinformation. The method provided by the invention can more effectively reflect the absorbable active ingredients of the medicinal materials and the contents thereof.

Description

technical field [0001] The invention relates to the field of processing and processing of decoction pieces of traditional Chinese medicine, in particular to a detection method and a quality control method of a rhodiola rosea medicinal material, especially a wall-breaking powder. Background technique [0002] Rhodiola Chinese medicine broken wall decoction pieces are Chinese medicine broken wall decoction pieces made of Rhodiola rosea as raw material by modern ultrafine crushing wall breaking technology. Rhodiola is the dry root and rhizome of Rhodiolacrenulata (Hook.f.et Thoms.) H.Ohba, a sedum plant. It has the effects of invigorating qi and activating blood circulation, dredging channels and relieving asthma, and is used for qi deficiency and blood stasis, chest obstruction and heartache, apoplexy hemiplegia, fatigue and asthma. Modern pharmacological studies have shown that Rhodiola rosea has the effect of improving hypoxia tolerance. Rhodiola rosea can reduce the damage...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/74G01N30/86
CPCG01N30/06G01N30/74G01N30/8686
Inventor 黄勇徐浩坤谢宇
Owner GUIZHOU GUANGJITANG PHARMA
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