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PH-responsive pyraclostrobin controlled release agent as well as preparation method and application thereof

A technology of pyraclostrobin and controlled release agent, which is applied in the field of pH-responsive pyraclostrobin controlled release agent and its preparation, and can solve problems such as limiting practical application effect and the like

Inactive Publication Date: 2021-01-26
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the easy photolysis of pyraclostrobin requires multiple sprays to ensure the efficacy in field application, which greatly limits its practical application effect (Fulcher et al., 2014)

Method used

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  • PH-responsive pyraclostrobin controlled release agent as well as preparation method and application thereof
  • PH-responsive pyraclostrobin controlled release agent as well as preparation method and application thereof
  • PH-responsive pyraclostrobin controlled release agent as well as preparation method and application thereof

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Experimental program
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Embodiment

[0037] 1 Materials and methods

[0038] 1.1 Reagents and materials

[0039] The original drug of pyraclostrobin (purity 97.5%) was purchased from BASF Europe (Limburgerhof, Germany); cetyltrimethylammonium bromide (CTAB), ethyl acetate, sodium hydroxide, ethyl orthosilicate (TEOS), tannic acid (TA), 3-aminopropyltriethoxysilane (APTES), copper chloride, tris(hydroxymethyl)aminomethane (Tris), hydrochloric acid, acetic acid, methanol and ethanol, all Analytical grade was purchased from Sinopharm Chemical Reagent Beijing Co., Ltd. (Beijing, China); chromatographic grade methanol was purchased from J.T. Baker Company (Philipsburg, USA); all experimental water was Milli-Q water, which was purchased from Millipore Corporation Mill-Q Ultrapure water preparation system purification was obtained (Billerica, USA).

[0040] 1.2 Preparation of PYR@MSNs-TA-Cu nanoparticles

[0041] Synthesis of mesoporous silica nanoparticles (MSNs): MSNs were prepared according to the method described...

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Abstract

The invention discloses a pH-responsive pyraclostrobin controlled release agent as well as a preparation method and application thereof. Amino-functionalized mesoporous silica nanoparticles MSNs-NH2 are taken as a carrier material, and a bactericide pyraclostrobin is loaded into mesoporous channels of the MSNs-NH2 nanoparticles through a physical adsorption method; and depositing on the surfaces of the drug-loaded MSNs-NH2 nanoparticles is conducted by utilizing the coordination effect of tannic acid TA and metal ions to form a metal-polyphenol network structure to block mesopores, thereby preparing the pH-responsive pyraclostrobin controlled release agent. UV photolysis experiment results show that the product has the effect of shielding ultraviolet photolysis of pyraclostrobin; controlled release kinetics show that the drug-loaded nanoparticles have different release properties under different pH conditions, have antibacterial activity equal to that of an original drug when diseasesoccur, and have a good application prospect in the field of precision agriculture as a novel agricultural bactericide.

Description

technical field [0001] The invention belongs to the technical field of pesticide formulations, and in particular relates to a pH-responsive pyraclostrobin controlled-release agent and a preparation method and application thereof. Background technique [0002] Rice sheath blight (Rhizoctonia solani) is one of the most serious diseases of rice, which can reduce rice yield by 25-40% every year (Srivastava et al., 2016). In the early stage of the disease, the pathogen of rice sheath blight can secrete oxalic acid to cause water-soaked lesions on the sheaths of the lower leaves of rice (Karmakar et al., 2016; Nagarajkumar et al., 2005). As an important pathogenic factor, oxalic acid can acidify the host tissue and reduce the local pH of the plant to about 4.5, which is beneficial to enhance the activity of extracellular enzymes of pathogenic fungi, and cooperate with cell wall degrading enzymes to accelerate the degradation of plant cell walls, eventually leading to the death of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/24A01N25/18A01N25/08A01P3/00A01P1/00
CPCA01N25/08A01N25/18A01N47/24Y02A40/10
Inventor 梁友霍中洋宋杰辉陈国奇
Owner YANGZHOU UNIV
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