Holmium laser lithotripsy protection liquid for protecting kidney tissues

A technology of holmium laser and protective solution, which is applied in the field of laser lithotripsy protection in the body, can solve the problems of large damage to kidney tissue, inability to use lithotripsy, and damage to kidney function. Effect

Active Publication Date: 2021-02-02
HEFEI CURESTAR LASER DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acid stones are not effective; neodymium lasers cannot be used for lithotripsy due to their less precise
The traditional laser lithotripsy is just a skin and an optical fiber. The laser of the lithotripsy can be transmitted to the optical fiber sleeve of the holmium laser lithotripsy equipment through the optical fiber. The optical fiber sleeve of the holmium laser lithotripsy equipment is just a hard glass fiber. The probe can transmit the laser light to the position of the kidney stone, crush the kidney stone, and excrete it through the renal tubule along with the urine, but the optical fiber sleeve of the traditional holmium laser lithotripsy equipment is harmful to the kidney tissue The damage is relatively large, and the surrounding kidney tissue will heat up due to the side effects of the laser, causing irreversible cell damage and damaging kidney function

Method used

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  • Holmium laser lithotripsy protection liquid for protecting kidney tissues
  • Holmium laser lithotripsy protection liquid for protecting kidney tissues
  • Holmium laser lithotripsy protection liquid for protecting kidney tissues

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Based on the optical fiber sleeve of the above-mentioned holmium laser lithotripsy equipment, the applicant provides a holmium laser lithotripsy protective solution for protecting kidney tissue according to its characteristics. The protective solution must be able to absorb a large amount of heat generated by the holmium laser during work, and Harmless to the body, high specific heat capacity, moderate fluidity, neither too strong nor too poor fluidity, if the fluidity is too strong, it is easy to flow everywhere along the gaps in human tissue, and it is not easy to suck out, which requires the self-absorption of human tissue , bring an extra burden to the patient's body, if the fluidity is too poor, the resistance of injection and suction is too great to be registered on the surface of the stone, and thirdly, it must be a medical non-toxic and harmless substance, for which the applicant provides A holmium laser lithotripsy protective solution was developed. The holmium...

Embodiment 2

[0044] A holmium laser lithotripsy protective fluid. The holmium laser lithotripsy protection solution comprises iron sucrose injection, chitosan, sodium chloride, oleanolic acid and PBS buffer solution, wherein, oleanolic acid accounts for 0.15% by mass volume, and chitosan accounts for 0.15% by mass volume. The volume ratio accounts for 0.3%, the sodium chloride accounts for 0.9% by mass volume ratio, and the iron sucrose injection accounts for 5% by volume ratio, and its preparation method is as follows.

[0045] Prepare a mixed solution with a final concentration of oleanolic acid 3 mg / mL, chitosan 6 mg / mL and sodium chloride 9 mg / mL with PBS buffer solution with a pH of 7.0 in a beaker, and in a 37 °C, 180w ultrasonic environment The mixed solution of oleanolic acid chitosan and sodium chloride was ultrasonically treated for 20 min. After ultrasonic treatment, the oleanolic acid chitosan sodium chloride solution was heated to 90° C., kept for 120 min, and then cooled at ...

Embodiment 3

[0049] A holmium laser lithotripsy protective solution. The holmium laser lithotripsy protection solution comprises iron sucrose injection, chitosan, sodium chloride, oleanolic acid and PBS buffer solution, wherein, oleanolic acid accounts for 0.02% by mass to volume, and chitosan accounts for 0.02% by mass volume. The volume ratio accounts for 0.05%, the sodium chloride accounts for 0.9% by mass volume ratio, and the iron sucrose injection accounts for 1% by volume ratio, and its preparation method is as follows.

[0050] Prepare a mixed solution with a final concentration of oleanolic acid 0.4 mg / mL, chitosan 1 mg / mL and sodium chloride 9 mg / mL with PBS buffer solution with a pH of 7.4 in a beaker, and prepare the mixed solution at 38 °C in an ultrasonic environment of 120w The mixed solution of oleanolic acid chitosan and sodium chloride was ultrasonically treated for 10 minutes. After ultrasonic treatment, the oleanolic acid chitosan sodium chloride solution was heated to...

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Abstract

The present invention provides holmium laser lithotripsy protection liquid for protecting kidney tissues, and belongs to the technical field of in-vivo laser lithotripsy protection. The holmium laserlithotripsy protection liquid comprises the following components in a mass volume ratio: 0.2-0.15% of oleanolic acid, 0.05-0.3% of chitosan, 0.9% of sodium chloride and 1-5% of an iron sucrose injection. The holmium laser lithotripsy protection liquid is non-toxic and harmless, has extremely small side effects on human body, is not suitable for only a small part of special crowds, and has a wide application range. A preparation method is simple, a ratio is easy to master, and the holmium laser lithotripsy protection liquid can greatly reduce kidney injury of patients with kidney stones after use. The holmium laser lithotripsy protection liquid has very strong practicability.

Description

Technical field: [0001] The invention belongs to the technical field of laser lithotripsy protection in vivo, and relates to a holmium laser lithotripsy protection liquid for protecting kidney tissue. Background technique: [0002] Holmium laser uses yttrium aluminum garnet (YAG) as the active medium, doped with sensitizing ion chromium (Cr), energy transfer ion thulium (Tm), and active ion holmium (Ho) laser crystal (Cr:Tm:Ho:YAG) A new type of laser light produced by a pulsed solid-state laser device. It can be used in urology, ENT, dermatology, gynecology and other departments. The laser surgery is a non-invasive or minimally invasive surgery, and the patient's treatment pain is very small. [0003] Compared with commonly used extracorporeal shock wave lithotripsy and pneumatic ballistic lithotripsy, holmium laser lithotripsy has strong safety and wide applicability. Extracorporeal shock wave lithotripsy uses a hydraulic or electromagnetic shock wave generator to emit ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K9/08A61K47/02A61P41/00A61P13/12A61B18/26A61K31/56A61K31/722
CPCA61K31/56A61K31/722A61K33/26A61K9/0019A61K9/08A61K47/02A61P41/00A61P13/12A61B18/26A61B2018/00511A61K2300/00
Inventor 黄恒郑国
Owner HEFEI CURESTAR LASER DEVICE
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