Application of stilbene compounds in prevention and treatment of fungal diseases

A technology of stilbenes and compounds, applied in the direction of application, bactericide, biocide, etc., to achieve the effect of high bactericidal activity and wide bactericidal spectrum

Pending Publication Date: 2021-02-05
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, there are few research reports on natural stilbene comp...

Method used

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  • Application of stilbene compounds in prevention and treatment of fungal diseases
  • Application of stilbene compounds in prevention and treatment of fungal diseases
  • Application of stilbene compounds in prevention and treatment of fungal diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Compounds (1)-(8) are all purchased, resveratrol (1) CAS: 501-36-0, purity >98%, purchased from Anaiji Chemical; oxidized resveratrol ( 2) CAS: 29700-22-9, purity >98%, purchased from Nanjing Chunqiu Bioengineering Co., Ltd.; picatanol (3) CAS: 10083-24-6, purity >98%, purchased from Jiangsu Aikang Biotechnology Medicine; Benzene Moder (4) CAS: 79338-84-4, purity >98%, purchased from Wuhan Bingfeng Pharmaceutical Technology Co., Ltd.; pterostilbene (5) CAS: 537-42-8, purity >98%, Purchased from Shanghai Beide Pharmaceutical Technology Co., Ltd.; 3'-hydroxy pterostilbene (6) CAS: 475231-21-1, purity >98%, purchased from Chengdu Pufeide Biotechnology Co., Ltd.; 3,4',5- Trimethoxy-trans-stilbene (7) CAS: 22255-22-7, purity >98%, purchased from Jiangsu Aikang Biopharmaceuticals; polydatin (8) CAS: 27208-80-6, purity >98 %, purchased from Jiangsu Aikang Biomedicine.

Embodiment 2

[0013] Embodiment 2: Indoor antibacterial activity assay and result

[0014] The pathogenic fungi used in this experiment were strains stored at 4°C in the laboratory. Except for Aspergillus flavus, the medium used for other pathogenic fungi was potato agar dextrose medium (referred to as PDA). The medium used by Aspergillus flavus is yeast extract peptone glucose agar medium (referred to as YPG).

[0015] PDA medium formula: potato (peeled) 200g, glucose 20g, agar 15g, distilled water 1000mL, natural pH; -30 minutes, it can be punctured by a glass rod), filter with four layers of gauze, fill the beaker with water to 1000mL, add 15-20g agar according to the experimental needs, add 20g glucose, stir to make it fully dissolved, and then pack in In the Erlenmeyer flask, sterilize at 121°C for 20 minutes, cool down and set aside.

[0016] YPG medium formula: glucose 5g, yeast extract 5g, peptone 5g, agar 20g, natural pH; YPG medium preparation method: dissolve 5g glucose, 5g yea...

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Abstract

The invention belongs to the field of medicinal chemistry, and discloses new application of stilbene compounds. The invention particularly relates to application of the stilbene compounds in prevention and treatment of diseases caused by rhizoctonia solani, sclerotinia sclerotiorum, botrytis cinerea, Gibberella zeae, magnaporthe oryzae, Fusarium oxysporum vasinfectum , aspergillus niger, aspergillus flavus, Phyllosticta zeae, phytophthora capsici, Colletotrichum gloeosporioides and Didymella bryoniae.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and discloses a new application of a class of stilbene compounds, in particular to its use in the prevention and treatment of Rhizoctonia solani, Sclerotinia sclerotiorum, tomato Botrytis cinerea, wheat scab, and rice blast fungus. , Cotton Fusarium wilt, Aspergillus niger, Aspergillus flavus, Pointer corn leaf, Phytophthora capsici, Apple anthracnose, Watermelon blight caused by diseases. Background technique [0002] Plant disease is one of the most common and harmful diseases in crop cultivation. It is estimated that the economic loss caused by plant pathogenic fungi exceeds 200 billion US dollars every year. The use of pesticides is an important means to ensure high and stable crop yields in agricultural production. However, the long-term irrational use of pesticides has led to a series of problems such as reduced control effects, drug residues, and drug resistance. At the same time, it ha...

Claims

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Application Information

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IPC IPC(8): A01N31/16A01N43/16A01P3/00
CPCA01N31/16A01N43/16
Inventor 刘映前燕银芳胡勇梅杨程杰贺颖慧杜莎莎李虎王仁轩
Owner LANZHOU UNIVERSITY
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