Method for detecting cannabidiol in cosmetics

A detection method and cannabidiol technology are applied in the detection field of cannabidiol in cosmetics, which can solve the problems affecting the accurate detection of cannabidiol, and achieve the effects of stable and reliable quantitative detection results, high sensitivity and short analysis time.

Active Publication Date: 2021-02-12
NAT INST FOR FOOD & DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the matrix of cosmetics is diverse and complex. If the pre-treatment is not proper, it is easy to affect the accurate detection of cannabidiol

Method used

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  • Method for detecting cannabidiol in cosmetics
  • Method for detecting cannabidiol in cosmetics
  • Method for detecting cannabidiol in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The detection method of cannabidiol in embodiment 1 cosmetics

[0044] 1. Sample extraction

[0045] Accurately weigh 1g of the cosmetic sample (accurate to 0.001g) and place it in a 10mL stoppered colorimetric tube, add methanol to 10mL, and oscillate at high speed on a vortex mixer for 30s to fully mix the sample with the extraction solvent. Closed, ultrasonically extracted for 10 minutes, and allowed to stand at room temperature.

[0046] 2. Sample purification

[0047] After the sample was allowed to stand at room temperature, the sample was purified with a LUMTECH MPFC-QuEChERS (high lipid) ultrafiltration purification column (Beijing Lvmian Technology Co., Ltd.), filtered through a 0.22 μm polytetrafluoroethylene microporous membrane, and taken as continued The filtrate was used as the solution to be tested.

[0048] Due to the complexity of the cosmetic base and the large difference between different cosmetic bases, the present invention selects 3 kinds of fac...

Embodiment 2

[0060] Referring to the detection method of Example 1, the cosmetic samples added with three substances such as cannabidiol (CBD), tetrahydrocannabinol (THC) and cannabinol (CBC) were detected. The total ion chromatogram (TIC) of cannabidiol (CBD), tetrahydrocannabinol (THC) and cannabichromene (CBC) is shown in figure 1 . The mass spectrometry parameters, precursor ions and product ions of cannabidiol (CBD), tetrahydrocannabinol (THC) and cannabinol (CBC) are shown in Table 3.

[0061] Table 3 Mass spectrometry parameters and qualitative and quantitative ion pairs of cannabidiol (CBD), tetrahydrocannabinol (THC) and cannabichromene (CBC)

[0062]

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Abstract

The invention relates to the technical field of cosmetic detection, in particular to a method for detecting cannabidiol in cosmetics. The detection method comprises the following steps: mixing a sample with an extraction solvent, and performing ultrasonic extraction to obtain an extracting solution; adding the extracting solution into a purification column for purification, and filtering to obtaina target detection solution, wherein the purification column is an MPFC-QuEChERS high-fat ultrafiltration type purification column made of a nano composite material; analyzing and detecting a targetdetection liquid by adopting an ultra-high performance liquid chromatography triple quadrupole tandem mass spectrometry method. The detection method realizes the detection of cannabidiol in cosmetics,the analysis time is short, and qualitative and quantitative detection results are stable and reliable.

Description

technical field [0001] The invention relates to the technical field of cosmetic detection, in particular to a detection method for cannabidiol in cosmetics. Background technique [0002] Hemp (Cannabis sativa L., Hemp), also known as thread hemp, hemp, etc., is an annual Moraceae plant. According to the proportion of tetrahydrocannabinol (tetrahydrocannabinol, THC) contained in cannabis, it can usually be divided into two categories: industrial cannabis and drug cannabis. The maximum content of THC in industrial hemp does not exceed 0.3%, while the content of THC in drug marijuana is relatively high. Cannabinoids (CBs) currently isolated from cannabis mainly include cannabidiol (CBD), tetrahydrocannabinol, cannabinol (CBN) and cannabichromene (CBC). In recent years, research on cannabidiol and cannabis extracts has developed rapidly, and there have been many related reports. Cannabidiol is the main chemical component in industrial hemp. It has become a trend to use indust...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/884
Inventor 李莉李硕王海燕孙磊路勇
Owner NAT INST FOR FOOD & DRUG CONTROL
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