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A kind of polymer with sunscreen effect, its preparation method and application

A technology of polymer and organic sunscreen agent, applied in cosmetic preparations, preparations for skin care, pharmaceutical formulations, etc., to achieve the effects of solving photodegradation, improving photostability and reducing skin permeability

Active Publication Date: 2022-04-19
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantage of chemical sunscreen is that it feels good on the skin, fresh and breathable, and the skin does not feel heavy after application. Moreover, different chemical sunscreens have different light absorption wavelengths, so they can be mixed and matched to achieve the maximum protection effect; the disadvantages are mainly photodegradation and skin permeability problem

Method used

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  • A kind of polymer with sunscreen effect, its preparation method and application
  • A kind of polymer with sunscreen effect, its preparation method and application
  • A kind of polymer with sunscreen effect, its preparation method and application

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preparation example Construction

[0056] The present invention also provides a method for preparing a polymer with sunscreen effect, comprising the following steps:

[0057] Under the action of a catalyst, the polymer having the structure described in formula (VI) is subjected to a bridging reaction with organic sunscreen agent molecules to obtain a polymer having the structure represented in formula (I):

[0058]

[0059] Among them, R 1 , R 1 ’ and R 2 'independently selected from a hydrogen atom or an alkyl group;

[0060] R 2 selected from sunscreen groups containing ester groups or sunscreen groups containing amide groups;

[0061] R 4 selected from -COOH, -COOM, -OH or -NH 2 ; M is selected from Na or K;

[0062] n is the degree of polymerization, and the range of n is 5-60;

[0063] The organic sunscreen molecule is selected from hydroxyl-containing compounds, amino-containing compounds, halogen-containing compounds or carboxyl-containing compounds.

[0064] In the preparation method of the ...

Embodiment 1

[0091] Polyacrylic acid PAA (the polymer having the structure described in formula (VI), wherein, R 1 , R 1 ’ and R 2 ’ are hydrogen atoms, R 4 selected from -COOH) and 2,4-dihydroxybenzophenone BP (organic sunscreen molecule HO-R 3 , where R 3 have the structure shown in formula (1)) according to the molar ratio of 1:1 mixed in dioxane, the amount of dioxane and polyacrylic acid ratio is 40mL: 0.4g; add catalyst (EDC and DMAP, molar Ratio of 1.2:1.1), the molar ratio of the catalyst to polyacrylic acid is 1.1:1, stirring and reacting at 100°C for 48h, using a rotary evaporator (the temperature of the rotary evaporation is 45°C, the vacuum degree of the rotary evaporation is -0.09 MPa, the time of rotary evaporation is 40min) to remove the solvent dioxane of the reaction system, then, in the reaction system, add dichloromethane equal to the volume of dioxane, ultrasonic solubilization (ultrasonic power is 90%, the time is 10min), after fully dissolving, wash with an equal...

Embodiment 2

[0095] Polyacrylic acid PAA (the polymer having the structure described in formula (VI), wherein, R 1 , R 1 ’ and R 2 ’ are hydrogen atoms, R4 selected from -COOH) and 4-hydroxy-4'-methoxyavobenzone ABZ (organic sunscreen molecule HO-R 3 , where R 3 have the structure shown in formula (6)) according to the molar ratio of 1:1 mixed in dioxane, the amount of dioxane and polyacrylic acid ratio is 40mL: 0.4g; add catalyst (EDC and DMAP, molar Ratio of 1.2:1.1), the molar ratio of the catalyst to polyacrylic acid is 1.1:1, stirring and reacting at 110°C for 48h, using a rotary evaporator (the temperature of the rotary evaporation is 45°C, and the vacuum degree of the rotary evaporation is -0.09 MPa, the time of rotary evaporation is 40min) to remove the solvent dioxane of the reaction system, then, in the reaction system, add dichloromethane equal to the volume of dioxane, ultrasonic solubilization (ultrasonic power is 90%, the time is 10min), after fully dissolving, wash with ...

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Abstract

The invention relates to the technical field of cosmetics, in particular to a polymer with sunscreen function, its preparation method and application. The invention provides a polymer with sunscreen effect, which has a structure shown in formula (I); in formula (I), R 1 , R 1 ’ and R 2 'independently selected from a hydrogen atom or an alkyl group; R 2 It is selected from a sunscreen group bonded with an ester bond or a sunscreen group bonded with an amide bond; n is the degree of polymerization, and the range of n is 5-60. In the present invention, small organic molecules that act as sunscreens are incorporated into polymers through chemical reactions, which greatly reduces skin permeability while retaining the sunscreen effect, and at the same time, due to the coating of polymer chains, its photostability is also improved. To a certain extent, it solves the problem of photodegradation. Experimental results show that the sunscreen prepared from the polymer with sunscreen effect of the present invention greatly reduces skin permeability while retaining its sunscreen effect.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a polymer with sunscreen function, its preparation method and application. Background technique [0002] Ultraviolet rays in sunlight can damage human skin, and the long-wave part (wavelength is about 320-400nm) is called UVA, which can penetrate the surface layer of the skin, penetrate deep into the tissues below the dermis, and destroy fine structures such as collagen and elastic fiber tissues, making the The skin is sagging and aging, and may induce skin cancer; the medium and short wave part (wavelength is about 290-320nm) is called UVB, which can reduce the content of hyaluronic acid bound to water in the skin, dry the skin, accelerate the formation of melanin, and change the complexion. Darkness is also an important cause of skin sunburn. The main function of sunscreen is to reduce the damage of UVA and UVB to human skin. [0003] At present, sunscreens on the market ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F20/04C08F8/00C08F16/06A61K8/81A61Q17/04
CPCC08F8/00A61K8/8147A61K8/8129A61Q17/04C08F20/04C08F16/06
Inventor 张国庆侯智耀
Owner UNIV OF SCI & TECH OF CHINA