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A kind of method for extracting iridoids from Huanghuabaijian

A technology of iridoids and patinate, applied in organic chemistry methods, organic chemistry, etc.

Active Publication Date: 2021-08-20
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It can be seen that (4 β , 8 β )-8-methoxy-3-methyl-10-methenyl-2, 9-dioxetane[4.3.1.0 3,7 ]Decan-4-ol has broad application prospects, yet, there is no extraction from Patrinia plants (4 β ,8 β )-8-methoxy-3-methyl-10-methenyl-2, 9-dioxetane[4.3.1.0 3,7 ]Decan-4-ol report

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  • A kind of method for extracting iridoids from Huanghuabaijian
  • A kind of method for extracting iridoids from Huanghuabaijian

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Embodiment 1

[0025] A method for extracting iridoids from the whole plant of Patrinia chinensis, comprising the following steps:

[0026] 1) Use 9.1kg of dried Patrinia officinalis as raw material, crush it and extract it with 75% ethanol to obtain the extract (soak and extract at 50°C for 3 times, each time for 3 days, and combine the extract; The amount of 75% ethanol added is 25L), and the solvent is recovered under reduced pressure to obtain the extract; 60% ethanol, 80% ethanol and 95% ethanol gradient elution, collect 40% ethanol elution fraction;

[0027] 2) Mix the eluted part of 40% ethanol with 300~400 mesh silica gel according to the weight ratio of 1:30, then pack the sample into the column, elute with dichloromethane-methanol with a volume ratio of 20:1, detect it by thin layer chromatography, and combine the same groups Separate and recover the solvent under reduced pressure to obtain the crude product.

[0028]3) The crude product obtained in step 2) was mixed with silica ...

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Abstract

The invention discloses a method for extracting iridoid compounds from Patrinia chinensis: taking dried Patrinia chinensis as raw material, extracting with ethanol after crushing to obtain extract, and recovering the solvent under reduced pressure to obtain extract extract; The extract extract was dissolved in water, and after the macroporous resin column was loaded, it was sequentially eluted with 20% ethanol, 40% ethanol, 60% ethanol, 80% ethanol and 95% ethanol gradient, and the 40% ethanol eluted part was collected; The 40% ethanol eluted part was mixed with silica gel and packed into a column, eluted with dichloromethane-methanol at a volume ratio of 20:1, detected by thin-layer chromatography, combined with the same components and recovered the solvent under reduced pressure to obtain the product. The method of the invention is beneficial to the better development and utilization of the medicinal plant patinella, and is beneficial to the sustainable utilization of the plant; the extraction process of the invention is simple, the solvent can be recycled and utilized, the extraction amount is high, and it is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, in particular to a method of extracting iridoids (4 β , 8 β )-8-methoxy-3-methyl-10-methenyl-2, 9-dioxetane[4.3.1.0 3,7 ] decan-4-ol method. Background technique [0002] Huang Hua Pai Jiang ( Patrina scabiosaefolia Fisch.) is the genus Patridae (Valerianaceae) ( Patrinia Juss . )plant. Huang Hua Pai Jiang has the effects of clearing heat and detoxifying, breaking blood stasis and draining pus, and can be used to treat intestinal abscess, lung abscess, dysentery, postpartum stasis abdominal pain, etc. [0003] The natural compound (4) involved in the present invention β , 8 β )-8-methoxy-3-methyl-10-methenyl-2, 9-dioxetane[4.3.1.0 3,7 ]Decan-4-ol is first extracted and isolated from Patrinia chinensis, and belongs to a kind of iridoid compounds. (4 β , 8 β )-8-methoxy-3-methyl-10-methenyl-2, 9-dioxetane[4.3.1.0 3,7 ] The source of decan-4-ol is mainly concentrated in the P...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/08
CPCC07B2200/07C07D493/08
Inventor 刘振花康文艺马常阳崔丽丽蒙丽君王莉屈娇娇
Owner HENAN UNIVERSITY