Compound salvia miltiorrhiza concentrated pills and preparation method thereof

A technology of compound Danshen pills and concentrated pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of loss of active ingredients, cumbersome process steps of compound Danshen pills, etc., and achieve simple preparation process and reduce effective The effect of loss of ingredients and shortening of the process flow

Inactive Publication Date: 2021-02-26
爱民药业集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For this reason, the present invention provides a kind of compound Danshen concentrated pill and its preparation method, in order to solve the problem that the process step of preparing compound Danshen pill is cumbersome and the loss of active ingredients is relatively serious

Method used

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  • Compound salvia miltiorrhiza concentrated pills and preparation method thereof
  • Compound salvia miltiorrhiza concentrated pills and preparation method thereof
  • Compound salvia miltiorrhiza concentrated pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] A compound Danshen concentrated pill is prepared from the following raw materials in parts by weight: 1350g of Danshen, 423g of Panax notoginseng, and 24g of borneol;

[0026] The preparation method of described compound red sage root concentrated pill comprises the steps:

[0027] Weigh each raw material for subsequent use;

[0028] Participate in ethanol and heat to reflux for 1.5 hours, filter the extract, recover ethanol from the filtrate and concentrate to an appropriate amount, and set aside; Add water to the slag and decoct for 2 hours, filter the decoction, concentrate the filtrate to an appropriate amount, combine with the above concentrate, and concentrate to a thick paste.

[0029] After the cleaned and dried notoginseng medicinal material is crushed, use an ultrafine pulverizer to make ultrafine powder with a fineness of 400-1200 mesh, and mix it with the above-mentioned Danshen thick paste;

[0030] Get the above-mentioned superfine powder and mix well wi...

experiment example

[0041] 1. Determination of active ingredients The HPLC-DAD method is used to analyze the main active ingredient Tanshinone II in the compound Danshen concentrated pills obtained in the examples and comparative examples A , salvianolic acid B and total saponins of Panax notoginseng were measured, and the main instruments used in the experiment included Waters e2695 type high performance liquid chromatography (U.S.), Waters2695 type high performance liquid chromatography (U.S.), Shimadzu LC-2030 (Japan ), its active ingredient content is as shown in table 1:

[0042] The comparison table of main active ingredients in the compound red sage root concentrated pill that table 1 embodiment and comparative example obtain

[0043] Tanshinone Ⅱ A

Salvianolic acid B Panax notoginseng saponins Example Compound Danshen Concentrated Pills 1.67mg / g 26.5mg / g 47.1mg / g Comparative Example Compound Danshen Concentrated Pills 1.64mg / g 26.1mg / g 46.5mg / g ...

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Abstract

The invention discloses compound salvia miltiorrhiza concentrated pills and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The compound salvia miltiorrhiza concentrated pills are prepared from the following raw materials in parts by weight: 130-140 parts of salvia miltiorrhiza, 40-45 parts of pseudo-ginseng and 2-3 parts of borneol. The preparation method of the compound salvia miltiorrhiza concentrated pills comprises the following steps: weighing the raw materials for later use; extracting the salviae miltiorrhizae by adopting an ethanol extraction method, and concentrating to obtain salviae miltiorrhizae thick paste; crushing cleaned and dried pseudo-ginseng medicinal material into fine powder, and uniformly mixing the fine powder withthe salvia miltiorrhiza thick paste; and grinding the borneol, dissolving the borneol with ethanol, uniformly mixing with the pseudo-ginseng fine powder and the salvia miltiorrhiza thick paste, pelleting, drying at low temperature, and coating with films to obtain the compound salvia miltiorrhiza concentrated pills. According to the preparation method of the compound salvia miltiorrhiza concentrated pills, a drying process is reduced in the mixing stage of the raw materials, the process is reduced, the loss of effective components is reduced, and the efficacy is better.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a compound Danshen concentrated pill and a preparation method thereof. Background technique [0002] Compound Danshen Pill (concentrated pill) is a famous Chinese patent medicine for treating cardiovascular diseases. It consists of salvia, notoginseng, borneol. Compound Danshen Pills (concentrated pills) have the effects of promoting blood circulation and removing blood stasis, fragrance and resuscitation, regulating qi and relieving pain, and are mainly used to treat chest tightness, upset, angina pectoris, insomnia, etc. caused by coronary heart disease. different. [0003] In the preparation process of Compound Danshen Pills, the setting of various process conditions, specific operation steps and detailed parameters are very important. Any change in process conditions and deletion of operation steps will have unpredictable effects on the final drug qual...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61P9/10A61P25/20A61K36/258A61K31/045
CPCA61K36/537A61K36/258A61K31/045A61K9/20A61P9/10A61P25/20A61K2236/333A61K2236/331A61K2236/39A61K2236/51A61K2236/15
Inventor 王楠熊梦华
Owner 爱民药业集团股份有限公司
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