Verifiable gene data outsourcing query protocol and verifiable gene data outsourcing query system
A genetic data and protocol technology, applied in the field of verifiable genetic data outsourcing query protocols and systems, can solve the problem that query users cannot verify the correctness of the results.
Active Publication Date: 2021-02-26
JINAN UNIVERSITY
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However, since the two cloud servers cannot collude, the query user cannot verify the correctness of the results
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[0061] This embodiment discloses a verifiable genetic data outsourcing query protocol, which can be applied in a genetic data outsourcing query system including genetic data owners, query users and cloud servers. Among them, the owner of genetic data can be multiple independent database institutions that provide original data sets, which can be represented by DO. Query users can be represented by Client, which includes non-genetic data owners and genetic data owners, that is to say, query users can be general users who only initiate query requests, or also serve as genetic data owners who provide genetic data.
[0062] DO holds the gene variation data set VCF (Variant Call Format), VCF={vcf 1 ,vcf,…,vcf i ,...,vcf m}, where 1≤i≤m, i represents the number of the vcf file in the genetic variation data set VCF, and m represents the size of the genetic variation data set owned by each genetic data owner, that is, the total number of vcf files in the genetic variation data set VC...
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The invention discloses a verifiable gene data outsourcing query protocol and system, and the method comprises the steps that a gene data owner ranks a gene variation data set held by the gene data owner, locally calculates a verification value and encrypted gene variation data of the gene variation data set, and uploads the encrypted data and the verification value to a cloud server; the cloud server calculates a verification value of the gene variation data set; a query user initiates a query to the gene variation data set of the cloud server, and queries whether variation on a certain chromosome exists in the gene variation data set of the gene data owner or not; the cloud server performs searching according to a query demand of a query user, and then sends a query result and a corresponding verification value to the query user; the query user judges whether the verification value returned by the cloud server is equal to the verification value stored locally by the query user or not, if yes, verification is passed, and the query result is correct; otherwise, the verification fails, and query is performed again. According to the invention, gene data outsourcing query can be realized efficiently and safely.
Description
technical field [0001] The invention relates to the technical field of genetic data outsourcing query, in particular to a verifiable genetic data outsourcing query protocol and system. Background technique [0002] As the cost of second-generation gene sequencing continues to decrease, it is becoming easier to obtain genetic data. Genetic data analysis is an important means to explore the health and safety of human life. Privacy protection has become one of the important issues in the field of information security. In other words, in the entire life cycle of genetic data analysis, the privacy of data is guaranteed, that is, the data is available but not visible. [0003] In the whole life cycle of genetic data analysis, a very important part is the secure query of genetic data, that is, the query user and the genetic data owner can obtain query information without revealing their respective input privacy information. result. With the continuous improvement of cloud storag...
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IPC IPC(8): G06F16/22G16B20/20G06F16/242G06F21/62G06F16/23
CPCG06F16/2255G16B20/20G06F16/2433G06F21/6218G06F16/23
Inventor 杨雅希翁健刘家男李明董彩芹李宇娴毛宜军
Owner JINAN UNIVERSITY