Preparation method and application of xanthotoxol water-soluble nano new dosage form

A water-soluble technology of Zanthoxylum bungeanum, which is applied in the biological field, can solve the problems of low bioavailability, poor drug extraction effect, and poor solubility of Zanthoxylum bungeanum in water.

Pending Publication Date: 2021-03-02
川北医学院附属医院
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Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a preparation method and application of a new water-soluble nanometer dosage form of xanthoxylin, which solves the problems of poor solubility in water, poor drug extraction effect and low bioavailability of xanthoxylin

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  • Preparation method and application of xanthotoxol water-soluble nano new dosage form

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Embodiment Construction

[0017] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0018] see figure 1 , the present invention provides a technical solution: a method for preparing a new water-soluble nano dosage form of xanthoxylin xanthophyll, specifically comprising the following steps:

[0019] S1. Dissolve poloxamer and dextrose in 100ml of hydrochloric acid, emulsify at high speed with an emulsifier, slowly add 1g of sodium salt drop by drop, continue to emulsify, then transfer to a magnetic stirrer and stir at 1000rpm for 20h, pass th...

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Abstract

,The invention discloses a preparation method and application of a xanthotoxol water-soluble nano new dosage form. The preparation method specifically comprises the following steps: S1, dissolving poloxamer and dextrose liver in 100ml of hydrochloric acid, performing emulsifying at a high speed by using an emulsifier, slowly dropwise adding 1g of sodium salt, continuing emulsifying, transferring emulsified material to a magnetic stirrer, performing stirring at 1000rpm for 20h, and performing an orthogonal test to find that the pH value is 4, the poloxamer content is 0.5, and prepared PBCA nanoparticles are optimal when the dextrose liver is 0.5; and S2, weighing a prescription amount of XT, polylactic acid and lecithin cholesterol ester acyltransferase, and performing dissolving in a certain amount of dichloromethane. The invention relates to the technical field of biology. According to the preparation method and the application of the xanthotoxol water-soluble nano new dosage form, the problems of water solubility and targeting are solved, and physiological barriers such as skin, mucous membranes and cell membranes are effectively overcome by the method. The secondary drug resistance phenomenon is avoided, and the immune response level is reduced. Meanwhile, the new dosage form can also be used for other traditional Chinese medicine component carriers to improve the bioavailability and the medicine effect.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a preparation method and application of a new water-soluble nanometer dosage form of xanthophyll. Background technique [0002] At present, the incidence of coronary heart disease in my country is generally on the rise. The most common and serious consequence of this disease is acute myocardial infarction. Although timely revascularization has saved some patients with acute ischemia, myocardial Ischemia / reperfusion injury. Myocardial I / R injury weakens the efficacy of revascularization therapy, and most myocardial infarction patients will eventually develop heart failure; it seriously endangers the health of Chinese people and brings a heavy burden to society and families. [0003] Zanthoxylin is a linear furanocoumarin, which exists in Umbelliferae, Rutaceae, Moraceae, Acanthaceae and Rhamnaceae plants, mainly derived from Umbelliferae Cnidium, Angelica dahurica, etc. Melting point...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/36A61K31/37A61P9/10
CPCA61K9/5161A61K31/37A61P9/10
Inventor 胡厚祥张荣驿岳荣川吕明明
Owner 川北医学院附属医院
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