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Traditional Chinese medicine small-molecule inhibitor of ROR[gamma]t

A technology of small molecule compounds and traditional Chinese medicines, which can be used in the application field of diseases and can solve the problems of biological activity and mechanism of action that need further research.

Inactive Publication Date: 2021-03-09
TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that procurantin has anti-tumor activity, but its biological activity and mechanism of action need to be further studied

Method used

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  • Traditional Chinese medicine small-molecule inhibitor of ROR[gamma]t
  • Traditional Chinese medicine small-molecule inhibitor of ROR[gamma]t
  • Traditional Chinese medicine small-molecule inhibitor of ROR[gamma]t

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Embodiment Construction

[0023] In order to enable those skilled in the art to better understand the technical solution of the present invention, the present invention is further described in the following examples. Among them, the small molecule of the traditional Chinese medicine to be studied in the present invention was purchased from Chengdu Durst Biotechnology Co., Ltd. The specific information is as follows: the purity of triptolide A is 99.16%, the molecular formula is C30H46O3, and the molecular weight is 454.68; the purity of isosilibinin is 99.11%, the molecular formula is C25H22O10, and the molecular weight is 482.44; C26H40O8, the molecular weight is 480.05; the purity of neoandrographolide is 99.09%, the molecular formula is C26H40O8, and the molecular weight is 480.58.

[0024] 1. Materials and consumables

[0025]

[0026]

[0027] 2. Compound solution preparation and storage

[0028]DMSO storage solution, reference substance (SR1001) 100mM, test sample 10mM, store at room temp...

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Abstract

The invention relates to a purpose of a traditional Chinese medicine small-molecule inhibitor of retinoid-related orphan receptor [gamma]t (ROR[gamma]t) and a medicine composition of the traditional Chinese medicine small-molecule inhibitor in ROR[gamma]-meditated diseases.

Description

technical field [0001] The invention describes a traditional Chinese medicine small molecule inhibitor of retinoic acid receptor-related orphan receptor γt (RORγt) and its application in treating or preventing RORγt-mediated diseases. Background technique [0002] Retinoic acid receptor-related orphan receptors (RORs), also known as NF1R. It mainly includes three members (RORα, RORβ, RORγ). RORα is mainly distributed in the liver, skeletal muscle, skin, lung, adipose tissue, kidney, thymus, brain and blood; RORβ is mainly distributed in the central nervous system, and a small amount is distributed in the brain, retina and pineal gland. RORγ is further divided into two subtypes: RORγ1 and RORγ2 (also known as RORγt), and the former is expressed in liver, skeletal muscle, thymus, pancreas, adipose tissue, etc. The latter are only expressed on immune cells. (Chai et al., 2013, Pathophysiological role of orphan nuclear receptors RORs and its regulatory mechanism, Advances in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61K31/357A61K31/366A61K31/7048A61P19/02A61P17/06A61P1/00A61P11/06A61P11/00A61P17/00A61P7/00A61P7/04A61P31/20A61P29/00A61P31/22A61P1/02A61P17/10A61P19/00A61P11/02A61P1/18A61P19/08A61P27/02A61P21/04A61P33/10A61P31/12A61P31/08A61P35/00
CPCA61K31/585A61K31/357A61K31/366A61K31/7048A61P19/02A61P17/06A61P1/00A61P11/06A61P11/00A61P17/00A61P7/00A61P7/04A61P31/20A61P29/00A61P31/22A61P1/02A61P17/10A61P19/00A61P11/02A61P1/18A61P19/08A61P27/02A61P21/04A61P33/10A61P31/12A61P31/08A61P35/00
Inventor 林建平刘岯刘翠李金龙
Owner TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI