Cell communication analysis method and system
A technology of cell communication and analysis method, applied in biostatistics, bioinformatics, informatics, etc., to achieve a wide range of applications, easy in-depth interpretation, and easy correlation effects
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Embodiment 1
[0038] Such as figure 1 As shown, the present invention discloses a cell communication analysis method, including cell communication prediction and ligand-target gene regulatory prediction, the specific method is as follows:
[0039] Cell communication forecast
[0040] 1.1 Response to expression abundance analysis
[0041] Enter a single cell gene expression matrix, using the ligand-receptor information contained in the CellPhoneDB software, based on a cell expressing receptor and another cell expression ligand to analyze each pair of cell ligand-receptor pairs Express abundance.
[0042] This embodiment analyzes only the receptors and ligands that are larger than the cell expression of the threshold percentage percentage in a particular cluster (by default 10%). Only the top 25 pair of p-value is shown in the top 10 to the previous 10 to the expression abundance information ( figure 2 ). Preferably, the information specifically displayed by the graphic can be adjusted accordin...
Embodiment 2
[0062] Such as Figure 7 As shown, the present invention also provides a cell communication analysis system including a cell communication prediction module and a ligand-target gene regulatory prediction module;
[0063] The cell communication prediction module includes:
[0064] Responsible to the expression abundance analysis unit for inputting a single cell gene expression matrix, using the ligand-receptor information contained in the CellPhoneDB software, based on a cell expressing receptor and another cell expression ligand Each pair of ligands - receptor pairs have abundance.
[0065] The surrogate pair number analysis unit is used to obtain the number of surcharges expressed in each of the cells based on the analysis of the abundance of each pair of cells - receptor on each pair of cells, whereby the cells can be obtained. The communication relationship is preliminary assessment.
[0066] Significantly enrichment of the surcharge to the number of analytical units for compar...
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