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Etimicin sulfate suppository as well as preparation method and application thereof

A technology of etimicin sulfate and mixing suppositories, which is applied in suppository delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., and can solve problems such as life-threatening, systemic or localized infections, and slow onset of action , to achieve the effects of controllable quality, simple preparation method and easy operation

Inactive Publication Date: 2021-03-19
WUXI JIMIN KEXIN SHANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Now there are injection and freeze-dried preparations on sale. The two dosage forms are used as intravenous infusion. The injections are more toxic, and improper handling is likely to cause systemic or local infection. If the infusion is too fast, it is easy to cause adverse reactions, which can be serious. life threatening
Sprays and atomized inhalation solvents are prone to adhesion, the efficacy of the medicine is easily weakened, and the onset of action is slow
[0006] In the etimicin sulfate preparation disclosed in the prior art, except injection, freeze-dried preparation, atomized inhalation and liposome inhalation, there is no development of suppository

Method used

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  • Etimicin sulfate suppository as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Etimicin Sulfate Suppository

[0044] Etimicin Sulphate 50-300mg

[0045] Additive 50-100mg

[0046] suppository base 750-900mg

[0047] The preparation method comprises mixing the raw material of etimicin sulfate and the suppository base in proportion to prepare suppository granules.

Embodiment 2

[0049] Etimicin Sulfate 50mg

[0050] Paraffin, glycerin 100mg

[0051] Cocoa butter about 825mg

[0052] Take cocoa butter and melt it on a water bath, add etimicin sulfate, paraffin, and glycerin to the above-mentioned melted matrix, disperse evenly, and keep warm and fill the mold.

Embodiment 3

[0054] The etimicin sulfate suppository is mixed with the etimicin sulfate raw material and the suppository base according to the following ratio to make suppository granule etimicin sulfuric acid 60-150mg

[0055] Additive 60-120mg

[0056] suppository base 750-900mg

[0057] Preferably, the etimicin sulfate suppository is made into suppository granules after mixing the etimicin sulfate crude drug with the suppository base in the following ratio (making about 1g / grain)

[0058] Etimicin Sulfate 100mg

[0059] Paraffin, glycerin 100mg

[0060] Semi-synthetic coconut oil ester about 775mg

[0061] Take semi-synthetic coconut oil ester and melt it on a water bath, add etimicin sulfate, paraffin, and glycerin to the above-mentioned melted matrix to disperse evenly, and heat-preserve and fill the mold.

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PUM

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Abstract

The invention relates to an etimicin sulfate suppository as well as a preparation method and application thereof. The etimicin sulfate suppository is prepared from the following components in parts byweight: 50-500 parts of etimicin sulfate, 50-200 parts of an additive and 500-2000 parts of suppository matrix, and each suppository is 1-3g in weight.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an etimicin sulfate suppository and a preparation method and application thereof. Background technique [0002] Etimicin sulfate, also known as adamicin, has the following structural formula [0003] [0004] Belongs to semi-synthetic aminoglycoside antibiotics. Indications for sensitive Escherichia coli, Klebsiella pneumoniae, Serratia, Citrobacter, Enterobacter, Acinetobacter, Proteus, Haemophilus influenzae and Staphylococcus of various infections. [0005] Now there are injection and freeze-dried preparations on sale. The two dosage forms are used as intravenous infusion. The injections are more toxic, and improper handling is likely to cause systemic or local infection. If the infusion is too fast, it is easy to cause adverse reactions, which can be serious. words can be life-threatening. Sprays and atomized inhalation solvents are prone to adhesion, the effic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K31/7036A61K47/04A61K47/06A61K47/10A61K47/14A61K47/18A61K47/26A61K47/44A61K47/42A61P31/04
CPCA61K9/02A61K31/7036A61K47/06A61K47/10A61K47/14A61K47/44A61K47/26A61K47/02A61K47/18A61K47/42A61P31/04
Inventor 华梦丹王晓霞於江华
Owner WUXI JIMIN KEXIN SHANHE PHARMA
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