Application of overexpression of tox3 gene as a prognostic marker in liver cancer

A technology for gene overexpression and prognosis, applied in the field of molecular biology, can solve the problems of limited research on CD155 regulation
CN112522401BActive Publication Date: 2021-09-24PEOPLES HOSPITAL PEKING UNIV
2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
PEOPLES HOSPITAL PEKING UNIV
Publication Date
2021-09-24

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses the application of TOX3 gene overexpression as a liver cancer prognosis marker. The present invention uses genome-wide CRISPR activation library screening to find that TOX3 can inhibit the expression of checkpoint inhibitor CD155. Further analysis of immune infiltration using TCGA liver cancer RNA-seq data found that the expression level of TOX3 was significantly positively correlated with the infiltration frequency of NK cells in liver cancer tissues. Combined with the inhibitory effect of CD155 on NK cells, it was further suggested that TOX3 may activate NK cells by inhibiting CD155 , which is beneficial to the prognosis of liver cancer patients. Therefore, TOX3 has a certain potential application value as a prognostic indicator in liver cancer.
Need to check novelty before this filing date? Find Prior Art

Description

Technical field

[0001] The present invention relates to the field of molecular biology, in particular, the application relates to TOX3 overexpression in the liver as prognostic markers. Background technique

[0002] Hepatocellular carcinoma (HCC) is the most common clinical, one of the most aggressive malignant tumors worldwide about 500,000 new patients every year, and increasing year by year. Liver blood vessels having multiple, highly malignant, fast growth rate, a wide range of transfer and high rate of recurrence, clinical treatment is not ideal. Treatment is most effective treatment for primary liver cancer is surgical resection, but a higher recurrence rate, tumor recurrence rate was 40% in five years, but at a late stage when the disease most patients treatment, because they do not meet the indications for surgical treatment and there is a high recurrence rate after the loss of the opportunity to question radical treatment, therefore, to seek new prognostic markers and po...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More