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Star-shaped gold nanoparticles synthesized based on polyglutamic acid in one step and preparation method thereof

A technology of gold nanoparticles and polyglutamic acid, which is applied in the direction of nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, can solve the problems of cumbersome steps, reduce cytotoxicity, reduce complex factors, increase Effects of dispersibility and biocompatibility

Active Publication Date: 2021-03-26
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the synthesis method of the above materials does not require the use of toxic organic solvents and improves the biological stability and biocompatibility, the steps of material synthesis are still cumbersome

Method used

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  • Star-shaped gold nanoparticles synthesized based on polyglutamic acid in one step and preparation method thereof
  • Star-shaped gold nanoparticles synthesized based on polyglutamic acid in one step and preparation method thereof
  • Star-shaped gold nanoparticles synthesized based on polyglutamic acid in one step and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) 4 mg of γ-PGA was dissolved in 4 mL of 0.05M sodium bicarbonate solution, placed in a 5 mL centrifuge tube, and sonicated for 5 min.

[0029] (2) Take 1 mL of the above solution into a 10 mL reaction flask.

[0030] (3) 3.66 mL of 0.01 M PBS buffer solution with pH of 7.3 was added, and stirred for 5 min.

[0031] (4) Quickly add 106 μL of 24.13 mM HAuCl 4 , the above solution was stirred for 4h in the dark.

[0032] (5) Quickly add 287 μL of 445 mM NH 2 OH·HCl, and stirred for 40 min in the dark.

[0033] (6) 14000rpm, 8min centrifugation three times to obtain GNS.

[0034] The particle size of the obtained GNS based on one-step synthesis of γ-PGA is about 1 μm.

Embodiment 2

[0036] (1) 2 mg of γ-PGA was dissolved in 4 mL of 0.05M sodium bicarbonate solution, placed in a 5 mL centrifuge tube, and sonicated for 5 min.

[0037] (2)-(3) are the same as steps (2)-(3) in Example 1.

[0038] (4) Quickly add 106 μL of 12.07 mM HAuCl 4 , the above solution was stirred for 4h in the dark.

[0039] (5)-(6) are the same as steps (5)-(6) in Example 1.

[0040] The particle size of the obtained GNS based on one-step synthesis of γ-PGA is about 380 nm.

Embodiment 3

[0042] (1) 4 mg of γ-PGA was dissolved in 4 mL of 0.05M sodium bicarbonate solution, placed in a 5 mL centrifuge tube, and sonicated for 5 min.

[0043] (2)-(3) are the same as steps (2)-(3) in Example 1.

[0044] (4) Quickly add 106 μL of 12.07 mM HAuCl 4 , the above solution was stirred for 4h in the dark.

[0045] (5)-(6) are the same as steps (5)-(6) in Example 1.

[0046] The particle size of the obtained GNS based on one-step synthesis of γ-PGA is about 509 nm.

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Abstract

The invention discloses star-shaped gold nanoparticles synthesized based on polyglutamic acid in one step and a preparation method thereof. GNS is synthesized in one step by taking hydroxylamine hydrochloride (NH2OH.HCl) as a reducing agent and reducing chloroauric acid (HAuCl4) in situ in a gamma-PGA solution. According to the star-shaped gold nanoparticles synthesized based on polyglutamic acidin one step and the preparation method thereof, the size and morphology of GNS can be effectively controlled by adjusting the concentration of gamma-PGA, the concentration of HAuCl4, the concentrationof NH2OH.HCl, the pH value and the reduction time, and it is found that epsilon-polylysine (epsilon-PL) cannot obtain the star-structure nanoparticles under the same condition; and the size range ofthe prepared GNS is 230nm to 1 micron. The method is simple to operate, short in time consumption, low in material consumption, free of organic solvents, mild and controllable in synthesis condition and high in reproducibility.

Description

technical field [0001] The invention belongs to the field of nanomaterials and their preparation, in particular to a star-shaped gold nanoparticle (GNS) synthesized by one-step γ-PGA and a preparation method thereof. Background technique [0002] Gold nanomaterials (eg: gold nanospheres, gold nanorods, gold nanocages, gold nanostars) have broad application prospects in the field of biomedicine due to their unique physical and chemical properties. Among them, gold nanostars (GNSs) have shown excellent The photothermal effect has received extensive attention from scientists. At present, GNS is basically prepared by the gold seed-mediated method. Barbosa et al. used dimethylformamide as the organic solvent, 2-30 nm gold seeds, and the seed-mediated method to synthesize branched gold nanoparticles (Langmuir 2010, 26, 14943). –14950). Schuetz et al. reported a method for seed-mediated synthesis of gold nanostars using hydroquinone as reducing agent and capping agent, 10 nm gol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB22F9/24B82Y30/00B82Y40/00B22F1/0553B22F1/07B22F1/054
Inventor 申鹤云赵美君白林涛马俊杰
Owner BEIJING UNIV OF CHEM TECH
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