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Preparation and quality detection of traditional Chinese medicine compound liniment for preventing and treating cow mastitis

A technology for dairy cow mastitis and compound liniment, which is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. To avoid problems such as susceptibility, increase in preparation cost, and cumbersome preparation process, it can achieve the effect of good protection and treatment effect, safety and effectiveness, and simple preparation process.

Pending Publication Date: 2021-04-09
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the treatment method of traditional Chinese medicine preparations has many advantages compared to other treatment methods, in combination with the preparation of existing traditional Chinese medicine preparations, about 7-10 or more Chinese medicinal materials are generally used for extraction and preparation. The increase of medicinal materials not only increases the preparation cost, but also increased the cumbersome preparation process, resulting in low extraction rate and other shortcomings
In order to solve the defects of the existing traditional Chinese medicine preparation technology, we prepare by reducing the amount of Chinese medicinal materials used in the preparation, which can also achieve the therapeutic effect. At the same time, the existing methods generally only detect one or two index components for the quality inspection of traditional Chinese medicine preparations , cannot comprehensively test the internal quality of the preparation and ensure the safety and effectiveness of the preparation

Method used

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  • Preparation and quality detection of traditional Chinese medicine compound liniment for preventing and treating cow mastitis
  • Preparation and quality detection of traditional Chinese medicine compound liniment for preventing and treating cow mastitis
  • Preparation and quality detection of traditional Chinese medicine compound liniment for preventing and treating cow mastitis

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Effect test

Embodiment 1

[0032] A preparation method of traditional Chinese medicine compound liniment for preventing and treating dairy cow mastitis, comprising the following steps:

[0033] (1) Preparation of extract: take 3 g of toad venom, clean it, dry it, crush it into fine powder, add 150 mL of 80% ethanol, extract twice at 70°C under reflux for 90 minutes each time, combine the extracts, filter, and refrigerate for later use. Take 1000g of clove medicinal material, remove impurities, sieve to remove ash, mash, add 6 times the amount of water, soak for 2 hours, heat to 100°C for distillation, when the oil and water are separated, collect the volatile oil, repeat the extraction once, and let the collected volatile oil stand for 24 hours , filtered, and refrigerated for later use;

[0034] (2) Mix 10 g of squash gum and 5 g of sucrose glyceryl stearate evenly, add a small amount of water to dissolve it, and obtain a mixed solution;

[0035] (3) Combine the toad venom extract and clove volatile o...

Embodiment 2

[0037] A preparation method of traditional Chinese medicine compound liniment for preventing and treating dairy cow mastitis, comprising the following steps:

[0038] (1) Preparation of extract: take 4 g of toad venom, clean it, dry it, pulverize it into fine powder, add 200 mL of 80% ethanol, extract under reflux at 70°C for 3 times, each time for 60 minutes, combine the extracts, filter, and refrigerate for later use. Take 2000g of clove medicinal material, remove impurities, sieve to remove dust, mash, add 7 times the amount of water, soak for 1.5h, heat to 100°C for distillation, when the oil and water are separated, collect the volatile oil, repeat the extraction once, and let the collected volatile oil stand for 36 hours, filtered, and refrigerated for later use;

[0039] (2) Mix 12 g of squash gum and 8 g of sucrose glyceride stearate evenly, add a small amount of water to dissolve it, and obtain a mixed solution;

[0040] (3) Combine the toad venom extract and clove v...

Embodiment 3

[0042] A preparation method of traditional Chinese medicine compound liniment for preventing and treating dairy cow mastitis, comprising the following steps:

[0043] (1) Preparation of extract: take 5 g of toad venom, clean it, dry it, crush it into fine powder, add 300 mL of 80% ethanol, extract twice at 75°C under reflux for 90 minutes each time, combine the extracts, filter, and refrigerate for later use. Take 1500g of cloves, remove impurities, sieve to remove dust, mash, add 7 times the amount of water, soak for 2 hours, heat to 100°C for distillation, collect volatile oil when the oil and water are separated, repeat the extraction once, and let the collected volatile oil stand for 24 hours , filtered, and refrigerated for later use;

[0044] (2) Mix 10 g of squash gum and 10 g of sucrose glyceryl stearate evenly, add a small amount of water to dissolve it, and obtain a mixed solution;

[0045] (3) Combine the toad venom extract and clove volatile oil, add 10mL of polysor...

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Abstract

The invention discloses preparation and quality detection of a traditional Chinese medicine compound liniment for preventing and treating cow mastitis. The traditional Chinese medicine compound liniment is prepared from 1-5g of venenum bufonis, 500-2000g of clove, 5-30g of borneol, 5-20mL of polysorbate 80, 5-15g of sesbania gums, 5-10g of glyceryl sucrose stearate and the balance of solvent added to 1000mL, and the solvent comprises ethanol and propylene glycol in a volume ratio of 7: 3. The traditional Chinese medicine compound liniment developed by compounding three traditional Chinese medicines is simpler in components, lower in cost, scientific in pharmacology, clear in medicine effect, stable and controllable in preparation quality, remarkable in effect of preventing and treating the cow mastitis, natural, pollution-free and beneficial to popularization and application. Meanwhile, quantitative analysis is carried out by combining the advantages of a high-performance liquid chromatograph and a PAD detector, the content of cinobufagin, resibufogenin and eugenol can be measured simultaneously, the effect of comprehensively detecting the inherent quality and stability of a preparation can be achieved, and the safety and effectiveness of medications of the liniment are guaranteed.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, in particular to a preparation and quality testing method of a traditional Chinese medicine compound liniment for preventing and treating cow mastitis. Background technique [0002] Cow mastitis is one of the major diseases in dairy production. Its etiology is complex and diverse, which brings many difficulties to the prevention and treatment of dairy cow mastitis. Although a large amount of financial and material resources are invested in the research on the prevention and treatment of dairy cow mastitis every year, mastitis still belongs to the most difficult disease category to prevent and control. According to statistics, among the existing dairy cows in the world, more than 30% suffer from various types of mastitis. Huge economic losses are caused to the breeding industry every year. [0003] The current treatment methods for cow mastitis include antibiotic treatment, biologic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61K47/26A61K47/10A61K47/36A61P15/14G01N30/02G01N30/64A61K35/65A61K31/045
CPCA61K35/65A61K36/61A61K31/045A61K9/0041A61K47/26A61K47/10A61K47/36A61P15/14G01N30/02G01N30/64A61K2236/331A61K2236/39A61K2236/53G01N2030/047A61K2300/00
Inventor 何家康徐威万冰洁谢颖邓招游朱杜娟吴莉芩覃兰迁易丹丹刘霞
Owner GUANGXI UNIV
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