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Method for calculating individualized dosage of ATG for haploid hematopoietic stem cell transplantation

A technology of hematopoietic stem cells and computational methods, applied in the field of hematopoietic stem cell transplantation, can solve the problems of increased risk of GVHD, increased risk of infection in patients, increased risk of virus reactivation, etc.

Pending Publication Date: 2021-04-16
GENERAL HOSPITAL OF PLA
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Problems solved by technology

However, since my inventors added ATG to the transplant system, there is an increased risk of viral reactivation
The current dosage of ATG is generally 10 mg / Kg of ATG; at this dosage, some patients are at increased risk of infection and some patients are at increased risk of acute GVHD

Method used

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  • Method for calculating individualized dosage of ATG for haploid hematopoietic stem cell transplantation
  • Method for calculating individualized dosage of ATG for haploid hematopoietic stem cell transplantation
  • Method for calculating individualized dosage of ATG for haploid hematopoietic stem cell transplantation

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Embodiment Construction

[0035] Hereinafter, the present application will be described in detail in conjunction with the accompanying drawings.

[0036] The present invention builds an ATG individualized medication calculation platform for the existing haploid transplantation system, which can calculate the optimal ATG dosage for each patient. Under this dosage, it can prevent GVHD and reduce the virus reactivation rate at the same time. Objective To optimize the prevention program of GVHD in allogeneic hematopoietic stem cell transplantation system.

[0037] First, establish the detection method of ATG concentration

[0038] Culture human HUT-78 cells in vitro, take cells in logarithmic growth phase, and adjust the concentration to 1×10 6 pieces / ml. Incubate HUT-78T cells with 0.3ml patient serum for 30min at room temperature in the dark, wash twice with PBS; incubate the cells with 0.1mL PE-labeled goat anti-rabbit IgG (diluted 1:100) for 20min at room temperature in the dark, wash twice with PBS ...

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Abstract

The invention relates to a method for calculating the individualized dosage of ATG for haploid hematopoietic stem cell transplantation. The ATG drug dosage applied to a subject enables the area exposure range of the active ATG of the subject under the curve to be 135-155U / L.d. The optimal exposure range of AUC exposure of active ATG is 135-155U / L.d by analyzing ATG concentration data of 106 cases of haploid transplantation, and the ATG individualized dosahe calculation method is further obtained through computer simulation, so that the ATG dosage is individualized, finally, the GVHD and virus reactivation rate of the patient is reduced, a new treatment thought and scheme are provided for prevention of the GVHD, and finally, the survival rate of the hematological malignancy patient is improved.

Description

technical field [0001] This application relates to hematopoietic stem cell transplantation technology. Background technique [0002] Haploid hematopoietic stem cell transplantation has achieved remarkable clinical efficacy in the treatment of hematological malignancies, and has become the most important model of allogeneic hematopoietic stem cell transplantation in my country. Graft Versus Host Disease (GVHD, Graft Versus Host Disease), especially moderate and severe chronic GVHD, as a common complication of allogeneic transplantation, seriously reduces the early survival rate and long-term quality of life of patients, so far there is no effective treatment . Once GVHD occurs, it will seriously impair the quality of life of the survivors, and may even lead to long-term death after several years. It is an important problem that endangers the lives of patients after transplantation. Improving the prevention system of GVHD and achieving "prevention before it happens" is of fa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H70/40G16H20/10G01N21/64
Inventor 刘代红汪海涛窦立萍王莉莉吴晓雄
Owner GENERAL HOSPITAL OF PLA
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