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Novel brain glioma molecular typing method

A technology for glioma and molecular typing, which is applied in proteomics, instrumentation, health index calculation, etc., can solve the problems of low accuracy, avoid data falsification, improve accuracy, and improve the recovery rate of treatment.

Pending Publication Date: 2021-04-30
ZHENGZHOU UNIV
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AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new molecular typing method for glioma to solve the problem of low accuracy of the traditional molecular typing method for glioma proposed in the above-mentioned background technology

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  • Novel brain glioma molecular typing method
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Embodiment Construction

[0044] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0045] see Figure 1-3 , an embodiment provided by the present invention:

[0046] A new molecular typing method for glioma, comprising the following steps:

[0047] Step 1: Collect data

[0048] The gene expression profiles and clinical information data were obtained from databases, and five glioma cohorts were included in this study: TCGA-GBMLGG cohort (n=892), three CGGA cohorts (mRNA-array (n=301), mRNAseq_325 (n= 325) and mRNAseq_693 (n=693)) and Rembr...

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Abstract

The invention discloses a novel brain glioma molecular typing method which comprises the following steps: step 1, collecting data, acquiring gene expression profiles and clinical information data from a database, and collecting four independent immunotherapy queues from a public database, including (1) Roh queues: an anti-CTLA4 treatment queue and an anti-PD1 treatment queue; (2) GSE100797: an adoptive T cell treatment queue; and (3) GSE78220: an anti-PD1 treatment queue. the GRI values are obtained through a large amount of data, brain glioma molecules of different patients can be divided, the accuracy of brain glioma molecule division is improved, doctors can be assisted in conducting different types of division on the patients conveniently, scientific treatment is conducted on the patients through different treatment modes, the treatment rehabilitation rate of the patients is increased, and the treatment cost of the patients is reduced. The problem that the traditional brain glioma molecular typing accuracy is low is solved.

Description

technical field [0001] The invention relates to the technical field of glioma, in particular to a new molecular typing method for glioma. Background technique [0002] Glioma is the most common intracranial malignant tumor with high heterogeneity. Surgical treatment combined with radiotherapy and chemotherapy is the main treatment for glioma, but the overall situation is still not ideal, and the prognosis is very poor. Poor, especially in glioblastoma, in somatic cells, various mechanisms cause DNA damage, and then somatic mutations occur, which makes the cell genome constantly change, and various types of mutations continue to accumulate, forming a unique combination of mutation accumulation , each combination is a "mutation signature". The mutation signature systematically characterizes the accumulation of mutations that lead to cancer, and links the mutation process with the DNA damage mechanism and clinical characteristics, providing an in-depth analysis and grasp of the...

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Application Information

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IPC IPC(8): G16B50/00G16B20/50G16B40/00G16H50/30
CPCG16H50/30G16B20/50G16B40/00G16B50/00
Inventor 卢韬源刘灶渠李天晓唐垚郭德华段林刘伊滢何艳艳贺迎坤
Owner ZHENGZHOU UNIV
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