Apparatus for manufacturing electron microscope grid sample
An electron microscope and production device technology, applied in the preparation of test samples, measuring devices, circuits, etc., can solve the problems of difficult to check the arrangement of protein solutions, difficult to see grid holes, etc., and achieve the effect of low cost and improved production efficiency
Pending Publication Date: 2021-05-07
XTEM生物实验室有限公司
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Problems solved by technology
Therefore, it is difficult to observe the grid holes with an optical microscope, etc., and even if the grid holes can be observed, it is difficult to check whether the protein solution is arranged in the holes in an appropriate amount
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[0053] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. Before then, the terms or words used in the specification and claims should not be construed as being limited to their ordinary or dictionary meanings. Based on the concept that the inventor can properly define the terms in order to best explain the principle of his own invention, it should be understood as the meaning and concept consistent with the technical idea of the present invention.
[0054] Therefore, the embodiments described in this specification and the configurations shown in the drawings are only the most preferred embodiments of the present invention, and do not represent all technical concepts of the present invention. Therefore, at the time of this application, it should be understood that there are alternative equivalents.
[0055] A grid sample producing apparatus 10 for an electron microscope according to an embodime...
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The present invention provides an apparatus for manufacturing an electron microscope grid sample, which has an appropriate amount of a protein liquid disposed in a plurality of holes formed in a grid, the apparatus comprising: a frame having an internal space; a grid part, which is vertically provided on the upper side of the frame, is provided to be vertically movable, and holds the grid at the lower end thereof; a filter part, which is provided inside the frame so as to be movable and selectively absorbs the protein liquid in the grid held at one end of the grid part; a laser unit provided to one side of the filter part so as to emit a laser beam at the grid disposed at the one end of the grid part; a screen part disposed inside the frame so as to allow the laser beam emitted from the laser unit to be diffracted by the grid such that a diffraction image is displayed; and a liquid amount analysis unit for determining whether the protein liquid in the grid is disposed in the appropriate amount by analyzing the illuminance of the diffraction image displayed on the screen part.
Description
technical field [0001] The present invention relates to a grid sample production device, and more particularly, to a grid sample production device for an electron microscope capable of measuring in real time the amount of a protein solution arranged in a plurality of holes formed in a grid for an electron microscope To make a grid sample arranged with the appropriate amount of protein solution. Background technique [0002] Generally, a grid for an electron microscope is used to acquire an image of a protein solution by using an electron microscope, and has a diameter of several micrometers (μm) formed at intervals of several micrometers (μm) on a very thin carbon film called a porous grid. ) units of holes, and are mainly used in cryo-electron microscopy. That is, in a grid for an electron microscope, an image of a protein sample can be obtained using an electron microscope by applying a protein solution to wells formed in a regular arrangement. [0003] In other words, t...
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Patent Timeline
Login to View More IPC IPC(8): G01N21/47
CPCG01N1/42G01N21/4788G01N1/2813G01N2001/2826G01N2201/06113H01J37/261H01J37/28H01J2237/28
Inventor 河南出赵寅成
Owner XTEM生物实验室有限公司