Application of lactucopicrin in preparation of medicine for preventing and treating heart failure and pathological cardiac remodeling

A technology for leucanthin and heart failure, which can be applied in the field of biomedicine and can solve the problems of unknown application and the like

Active Publication Date: 2021-05-11
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing published technology mainly focuses on the extraction and preparation methods of radish bitterin, the application number is "202011063090.0", the application date is "2020.09.30", and the name is "A kind of radish bittern and its application as an anti-inflammatory ingredient "'s patent application specifically discloses the use of Lactucopicrin in the preparation of anti-inflammatory drugs; and the current application of medicinal materials with Lactucain as active ingredients in the preparation

Method used

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  • Application of lactucopicrin in preparation of medicine for preventing and treating heart failure and pathological cardiac remodeling
  • Application of lactucopicrin in preparation of medicine for preventing and treating heart failure and pathological cardiac remodeling
  • Application of lactucopicrin in preparation of medicine for preventing and treating heart failure and pathological cardiac remodeling

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Application of leucanthin in the preparation of medicaments for preventing and treating heart failure and pathological cardiac remodeling.

[0030] (1) Experimental animals

[0031] 12-week-old healthy male C57BL / 6J mice were provided by the Animal Experiment Center of the Air Force Military Medical University of the Chinese People's Liberation Army.

[0032] (2) Experimental materials

[0033] Lactocin (abbreviated as LCP, purity >95%) was purchased from Merck Sigma Company, product number PHL84796; Metoprolol (Metoprolol, purity >95%) was purchased from MedChemExpress Company, product code HY-17503.

[0034] (3) Animal model construction

[0035] The 12-week-old male C57BL6J mice underwent permanent ligation of the left anterior descending coronary artery for 28 days to establish a model of heart failure and pathological cardiac remodeling. The mice were randomly divided into 5 groups with 20 mice in each group, which were divided into: (1) Sham operation...

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PUM

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Abstract

The invention relates to the technical field of biological medicines, in particular to application of lactucopicrin in preparation of a medicine for preventing and treating heart failure and pathological cardiac remodeling. The medicine takes the lactucopicrin as an active ingredient, which can be mixed with pharmaceutically acceptable, inert and non-toxic excipients or carrier auxiliary materials to prepare the clinical medicine convenient for oral administration or intravenous application. Specifically, the invention relates to application of the lactucopicrin in preparation of a medicine for resisting heart failure, application of the lactucopicrin in preparation of a medicine for resisting cardiac insufficiency, application of the lactucopicrin in preparation of a medicine for resisting pathological cardiac remodeling, an effect of the lactucopicrin in preparation of a medicine for resisting cardiomyocyte hypertrophy, application of the lactucopicrin in preparation of a medicine for resisting myocardial interstitial fibrosis and application of the lactucopicrin in preparation of a medicine for resisting myocardial cell death.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of leucanthin in the preparation of medicaments for preventing and treating heart failure and pathological cardiac remodeling. Background technique [0002] Heart failure is a clinical syndrome manifested by the progression to the end stage of various cardiovascular diseases such as coronary atherosclerotic heart disease, myocardial infarction, hypertension, myocarditis and cardiomyopathy. A variety of symptoms caused by the inability to meet the blood supply to organs throughout the body. The key pathogenic mechanism of heart failure is pathological cardiac remodeling, which is mainly manifested by myocardial cell hypertrophy, myocardial interstitial fibrosis and myocardial cell death. How to effectively alleviate pathological cardiac remodeling becomes the prevention and treatment of heart failure and cardiac insufficiency. bottleneck link. [0003] At pre...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P9/04A61P9/00
CPCA61K31/365A61P9/04A61P9/00
Inventor 陈希瑶张富洋
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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