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Applications of statins in preparation of drugs for treating diabetic cardiomyopathy

A diabetes and drug technology, applied in the field of drug preparation, can solve the problem of no research on diabetic cardiomyopathy

Inactive Publication Date: 2021-05-18
THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research on the relationship between TLR4 / NF-κB and diabetic cardiomyopathy in the prior art
[0003] Through the above analysis, the existing problems and defects of the prior art are: there is no research on TLR4 / NF-κB and diabetic cardiomyopathy in the prior art

Method used

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  • Applications of statins in preparation of drugs for treating diabetic cardiomyopathy

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Embodiment Construction

[0026] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0027] Aiming at the problems existing in the prior art, the present invention provides a use of statins in the preparation of drugs for treating diabetic cardiomyopathy. The present invention will be described in detail below with reference to the accompanying drawings.

[0028] Use of the statins provided by the embodiments of the present invention in the preparation of medicines for regulating TLR4 / NF-κB and heart function.

[0029] The regulation provided by the embodiment of the present invention includes inhibiting the expression of TLR 4 / NF-κB and improving heart function.

[0030] The medicines provided by the embo...

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Abstract

The invention belongs to the technical field of drug preparation, and discloses applications of statins in preparation of drugs for treating diabetic cardiomyopathy. Applications of the statins in preparation of drugs for adjusting TLR 4 / NF-[kappa]B and cardiac functions and applications of the statins in preparation of drugs for treating, improving or reducing the danger or severity of diabetic cardiovascular complications are included. The inhibition effects of atorvastatin with different doses on diabetic myocardium TLR 4 / NF-[kappa]B and improvement effects on cardiac functions are firstly cleared. Through the observation of the expression of rat myocardium TLR 4 and the relationship between NF-[kappa]B activation and cardiac structures and functions and myocardial fibrosis and the concentration of angiotensin II in myocardial tissue, and the observation of changes of above indicators by adopting different doses of the atorvastatin to treat rats with diabetes, reference basis can be provided for the mechanism and clinical treatment of diabetic cardiomyopathy.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to the use of statins in the preparation of medicines for treating diabetic cardiomyopathy. Background technique [0002] At present, diabetic cardiomyopathy (dabe tic car do myopathy, DCM) is one of the main cardiovascular complications of diabetes. DCM manifests as diastolic dysfunction in the early stage, systolic dysfunction in the late stage, and finally the clinical manifestation of heart failure. The role of inflammatory response in the pathogenesis of diabetic cardiovascular disease complications has been paid more and more attention. TLR4 / NF-κB signal is a signal transduction system closely related to immune inflammation. Many studies have found that TLR 4 plays an important role in the complications of type 2 diabetes, among which the research on diabetic nephropathy is the most common. However, there is no research on TLR4 / NF-κB and diabetic car...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/40A61P3/10A61P9/00A61P9/04
CPCA61K45/00A61K31/40A61P3/10A61P9/00A61P9/04
Inventor 姜华王宏利郭妮娜丁彦春尹兴雯袁金鑫
Owner THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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