Production-type two-dimensional liquid chromatography interface and production-type two-dimensional liquid chromatography separation system

A two-dimensional liquid chromatography and separation system technology, which is applied in the field of production-type two-dimensional liquid chromatography interface and production-type two-dimensional liquid chromatography separation system, can solve the problems of small injection volume and two-dimensional separation synchronization that have not been thoroughly solved Solve and fail to complete large-scale sample preparation and other problems

Pending Publication Date: 2021-05-18
李宜珊
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Problems solved by technology

The injection volume of the analytical two-dimensional liquid chromatography system is very small. In order to realize the synchronization of the two-dimensional separation, the co-eluted chromatographic peak fractions are cut multiple times, resulting in a small amount, trace level or trace amount of the two-dimensional liquid chromatography separation. Level of repeated samp...

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  • Production-type two-dimensional liquid chromatography interface and production-type two-dimensional liquid chromatography separation system
  • Production-type two-dimensional liquid chromatography interface and production-type two-dimensional liquid chromatography separation system
  • Production-type two-dimensional liquid chromatography interface and production-type two-dimensional liquid chromatography separation system

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Embodiment

[0037] Example: A production-type two-dimensional liquid chromatography separation system structure

[0038] In this embodiment, the sampling method is first-dimensional pump injection, and the number of enrichment columns in the enrichment column array is 4, which are sequentially numbered as the first enrichment column, the second enrichment column, and the second enrichment column of the enrichment column array. 3 enrichment column, the 4th enrichment column; Figure 4 (a) is the first dimension loading state of the production type two-dimensional liquid chromatography separation system, and Figure 4 (b) is the state of the production type two-dimensional liquid chromatography separation system The first dimension and the second dimension work in parallel.

[0039] The following is the two-dimensional separation process control of the above-mentioned production-type two-dimensional liquid chromatography separation system structure:

[0040] First clean the enrichment column...

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Abstract

The invention provides a production-type two-dimensional liquid chromatography interface and a production-type two-dimensional liquid chromatography separation system. The production-type two-dimensional liquid chromatography interface comprises a production-type two-dimensional liquid chromatography interface, a first-dimensional liquid phase system and a second-dimensional liquid phase system. Through the production type two-dimensional liquid chromatogram interface based on the enrichment column array, the problems of synchronous conflict and control of first-dimensional liquid chromatogram separation and second-dimensional liquid chromatogram separation are solved, and continuous and efficient operation of production type two-dimensional liquid chromatogram separation can be realized.

Description

technical field [0001] The invention belongs to the technical field of high-performance liquid chromatography separation, and relates to a production-type two-dimensional liquid chromatography interface and a production-type two-dimensional liquid chromatography separation system. Background technique [0002] The operating modes of the online two-dimensional liquid chromatography system are divided into single heart-cutting, multiple heart-cutting and continuous cutting. In the process of two-dimensional chromatographic separation in multiple heart-cutting mode and continuous cutting mode, it is necessary to ensure that the two-dimensional separation is carried out simultaneously. In order to keep the first and second dimensions running synchronously, the gradient time of the second dimension must be smaller than the cutting time of the first dimension. For this reason, higher flow rates are required in the second dimension. Although a higher flow rate can further increas...

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Application Information

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IPC IPC(8): G01N30/08
CPCG01N30/08
Inventor 李宜珊
Owner 李宜珊
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