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Microfluidic module for co-encapsulation in droplets

An encapsulation module and microfluidic technology, which is applied in the direction of microsphere preparation, transportation and packaging, microcapsule preparation, etc., can solve the problems of not being able to control the merging of droplets well and not being able to classify

Active Publication Date: 2021-05-18
UNIV LIEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The downside of the droplet merging module is that it does not have a good control over the contents of the merged droplets since the generated droplets cannot be sorted before they reach the droplet merging module.

Method used

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  • Microfluidic module for co-encapsulation in droplets
  • Microfluidic module for co-encapsulation in droplets
  • Microfluidic module for co-encapsulation in droplets

Examples

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Embodiment Construction

[0145] figure 1A schematic diagram of an embodiment of the microfluidic module 100 of the present invention is shown. The microfluidic device 100 includes a first module 1, the first module 1 is used for generating a first group of liquid droplets, encapsulating the first group of liquid droplets, classifying the first group of liquid droplets and providing the first group of liquid droplets to Fusion module 3 to merge with another droplet in fusion module 3. The microfluidic device 100 includes a second module 2, the second module 2 is used to generate a second group of liquid droplets, encapsulate the second group of liquid droplets, classify the second group of liquid droplets and provide the second group of liquid droplets to Fusion module 3 to merge with another droplet in fusion module 3. The first module 1 and the second module 2 each comprise a generating and encapsulating module 10, 20 capable of providing a first population and a second population of encapsulated ...

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Abstract

Microfluidic module (100) for co-encapsulation in droplets of two populations of particles, comprising a first (1) and a second (2) modules for sorting said two populations, said modules (1, 2) having their first outlets (12, 22) comprising first obstructive valves (121, 221) configured to at least partially obstruct said first outlets (12, 22), said first outlets (12, 22) being fluidly connected to a fusion module (3) comprising: a fusion module means (30) for merging at least one droplet from the first droplet population and at least one droplet from the second droplet population into a merged droplet comprising said two population of particles, a control unit (4) for controlling said first obstructive valves (121, 221) from information originating from a first (19) and second (29) module detection portion located upstream of said first outlets (12, 22).

Description

technical field [0001] According to a first aspect, the invention relates to a microfluidic module for co-encapsulation of droplets. Background technique [0002] Microfluidics is the manipulation of fluids at the micron scale in specialized devices, often called microfluidic chips. It is particularly well suited for research and development in fields related to biology and chemistry. Due to the immiscibility of two liquids, such as oil and water, it is possible to generate droplets as small as a few picoliters in volume in a microfluidic chip. Aqueous droplets (water-in-oil droplets) can be produced in the immiscible continuous oil phase. In contrast, oil droplets (oil-in-water droplets) may form in the aqueous phase. The field concerned with the creation and use of droplets in microfluidics is known as droplet microfluidics, also known as two-phase, discrete, or droplet-based microfluidics. Monodisperse droplets (ie, of equal volume, spacing and frequency) are produced...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/04
CPCB01J13/04B01J13/08B01F23/41B01F33/301B01F33/3021B01F35/214B01F35/2211B01F35/71805B01F23/4143B01F23/4145B01F2101/23
Inventor 特里斯坦·吉莱特斯蒂芬妮·万洛
Owner UNIV LIEGE
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