Manufacturing method of a breast stent capable of promoting vascularization

A production method and vascularization technology, which are applied in the fields of fake breasts, image data processing, medical science, etc., can solve the problems of long time, loss of normal breast shape, and high cost, and can promote the regeneration of blood vessels and tissues in the body, which is conducive to the preservation of activity and function, the effect of avoiding the risk of contamination

Pending Publication Date: 2021-05-25
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Breast cancer is the malignant tumor with the highest incidence rate among women in the world. Modified radical mastectomy (total mastectomy) for breast cancer makes women lose their normal breast shape. Breast reconstruction is the only way to solve this problem. Because there are many existing breast reconstruction methods Insufficient, so the actual proportion of the operation in my country is less than 5%
Some 3D printing materials are not suitable for making breast substitutes, such as metal, resin, etc.; while others are technically difficult, costly, and time-consuming

Method used

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  • Manufacturing method of a breast stent capable of promoting vascularization
  • Manufacturing method of a breast stent capable of promoting vascularization
  • Manufacturing method of a breast stent capable of promoting vascularization

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A method for promoting breast stent vascularization, comprising the steps of:

[0033] (1) Obtain the breast imaging data of the patient through imaging CT, MRI scanning or DSA angiography, and then use CAD software for three-dimensional modeling to obtain slice STL format files, such as figure 2 As shown, the size of the stent meets the individual needs of patients with breast defects;

[0034] (2) Based on the above data analysis and model making, design the porous structure of the breast support, such as image 3 As shown, it facilitates the ingrowth of blood vessels and the release of vascular factors in biological scaffolds;

[0035] (3) Polyethylene glycol diacrylate (PEGDA) is dissolved in phosphate buffered saline with the concentration of 12% w / v, photoinitiator LAP with 2.5% w / v, tartrazine with 0.05% w / v, obtain absorbable liquid hydrogel material;

[0036] (4) Aseptically treat the absorbable liquid hydrogel material obtained in step (3), add it to a cen...

Embodiment 2

[0041] A method for promoting breast stent vascularization, comprising the steps of:

[0042] (1) Obtain the breast imaging data of the patient through imaging CT, MRI scanning or DSA angiography, and then use CAD software for three-dimensional modeling to obtain slice STL format files, such as figure 2 As shown, the size of the stent meets the individual needs of patients with breast defects;

[0043] (2) Based on the above data analysis and model making, design the porous structure of the breast support, such as image 3 As shown, it facilitates the ingrowth of blood vessels and the release of vascular factors in biological scaffolds;

[0044] ((3) Add polyethylene glycol diacrylate (PEGDA) with 14% w / v, photoinitiator LAP (phenyl-2,4,6-trimethylbenzoyl lithium phosphonate) with 2% w / v and tartrazine are dissolved in phosphate buffer solution at a concentration of 0.07% w / v to obtain an absorbable liquid hydrogel material;

[0045] (4) Aseptically treat the absorbable l...

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Abstract

The invention provides a manufacturing method of a breast stent capable of promoting vascularization, which comprises the following steps of: obtaining imaging data of a breast through imaging CT, MRI scanning, DSA angiography and the like, then modeling by utilizing CAD software, outputting a lamellar STL format file of the breast to be printed, taking a biodegradable material and living cells as printing raw materials, and finally, stacking and forming the materials according to the layer-by-layer stacking principle of a 3D printer. According to the invention, the integrated construction of the tissue scaffold and the cells can be realized through a biological 3D printing technology in which the living cells are directly used as a printing raw material, and the in-vitro operation time required in a traditional tissue engineering construction strategy is greatly shortened.

Description

technical field [0001] The invention relates to the field of tissue engineering breast reconstruction, in particular to a manufacturing method of a vascularized breast bracket. Background technique [0002] Breast cancer is the malignant tumor with the highest incidence rate among women in the world. Modified radical mastectomy (total mastectomy) for breast cancer makes women lose their normal breast shape. Breast reconstruction is the only way to solve this problem. Because there are many existing breast reconstruction methods Insufficient, so the actual proportion of the surgery in my country is less than 5%. [0003] At present, breast filling materials mainly include three categories: medical materials, autografts and tissue engineering products. Medical materials also include implantable prostheses such as silica gel, polyacrylamide gel, triacylglycerol (triglyceride), hyaluronic acid, and injection mixtures such as liquid paraffin and petrolatum. These materials are p...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61F2/12B33Y10/00B33Y50/00G06T17/00A61L27/38A61L27/18A61L27/50A61L27/54A61L27/56A61L27/58A61L27/40
CPCA61F2/12B33Y10/00B33Y50/00G06T17/00A61L27/3834A61L27/3839A61L27/18A61L27/50A61L27/54A61L27/56A61L27/58A61F2240/002A61F2210/0004A61L2430/04A61L2300/602A61L2430/40C08L71/02
Inventor姜文彬孙家明汪振星陈雳风
OwnerXIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV