Preparation method and application of nicotine salt

A technology of nicotine salt and nicotine, which is applied in the field of electronic cigarettes, can solve the problems of excessive smoking of nicotine, lack of quality control, poor salt stability and other problems, and achieve the effect of improving experience, improving stability and output, and improving taste

Active Publication Date: 2021-05-28
SHENZHEN IPURE BIO-TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a crystal, nicotine salt lacks quality control during the synthesis process, which may easily lead to partial crystallization or poor stability of the synthesized salt, resulting in lower yield
In addition, because nicotine salt has a softer throat hit than traditional nicotine, it will cause smokers to over-inhale nicotine and cause physical discomfort

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] The application provides a method for preparing nicotine salt, which includes the following steps: under stirring conditions, add diluent, organic acid and nicotine to the reactor in sequence, stir at 40-50°C for 4-6h, let stand, and cool to room temperature , crystallized to obtain nicotine salt.

[0034] Wherein, after adding diluent into the reactor, glycyrrhizic acid monopotassium salt is added into the reactor, and the weight ratio of nicotine to glycyrrhizic acid monopotassium salt is 1:0.6-0.8.

[0035] Glycyrrhizic acid monopotassium salt is obtained by extracting, precipitating and crystallizing crude glycyrrhizic acid. In some embodiments, the crude glycyrrhizic acid is extracted by a common solvent method, which will not be described here. In some embodiments, the preparation steps of monopotassium glycyrrhizic acid are as follows: the crude product of glycyrrhizic acid is reflux extracted with acetone to obtain an extract, and 20% potassium hydroxide soluti...

Embodiment 1

[0039] A method for preparing nicotine salt, comprising the steps of:

[0040] Under stirring conditions, 45 parts of 1,2-propanediol, 23 parts of glycerin, 4 parts of benzoic acid, 3 parts of anhydrous citric acid, 7 parts of lactic acid, 2 parts of malic acid, 1 part of acetic acid, 3 parts of glutamic acid and 15 Parts of nicotine were sequentially added into the reactor, stirred at 50°C for 4 hours, allowed to stand, cooled to room temperature, and crystallized to obtain nicotine salt.

Embodiment 2

[0042] A method for preparing nicotine salt, comprising the steps of:

[0043] Under stirring conditions, 45 parts of 1,2-propanediol, 23 parts of glycerin, 4 parts of benzoic acid, 3 parts of anhydrous citric acid, 7 parts of lactic acid, 2 parts of malic acid, 1 part of acetic acid, 3 parts of glutamic acid, 15 1 part of nicotine and 3 parts of Lycium barbarum polysaccharide were added into the reactor in sequence, stirred at 50°C for 4 hours, allowed to stand, cooled to room temperature, and crystallized to obtain nicotine salt.

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PUM

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Abstract

The invention relates to a preparation method and application of nicotine salt, and belongs to the technical field of electronic cigarettes. The preparation method comprises the following steps: sequentially adding a diluent, an organic acid and nicotine into a reactor under a stirring condition, stirring at 40-50 DEG C for 4-6 hours, standing, and cooling to the room temperature to obtain the nicotine salt. The yield of the prepared nicotine salt is greatly increased, the product is more stable and higher in quality, when the prepared nicotine salt is applied to the electronic cigarette, the quality of tobacco tar can be better controlled, the production efficiency is high, and the obtained product is more easily loved by consumers.

Description

technical field [0001] The present application relates to the technical field of electronic cigarettes, in particular to the preparation method and application of nicotine salt. Background technique [0002] Nicotine, commonly known as nicotine, is an alkaloid present in Solanaceae plants, which can be extracted from Nicotiana and Rhododendron. Nicotine is an important component in tobacco and an important indicator to measure the quality of tobacco. It contains about 2%-3% in tobacco leaves, accounting for about 95% of the total amount of tobacco alkaloids. In tobacco leaves, nicotine mainly exists in the form of nicotine salts, which is a major addictive component in tobacco, most of which are nicotine malate and nicotine citrate. [0003] E-cigarettes are non-combustible tobacco alternatives that have the same look, smoke, taste and feel as cigarettes. It is a product that allows users to inhale after turning liquid nicotine salt into steam by means of atomization. Com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24B15/167
CPCA24B15/167
Inventor 杨鹏卢帅苏磊刘巍俊王一骑唐泽龙
Owner SHENZHEN IPURE BIO-TECH CO LTD
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