The invention discloses a brain-refreshing and mind-regulating ointment and a preparation method thereof. The brain-refreshing and mind-regulating ointment mainly contains raw gypsum, raw oyster shell, ramulus cinnamomi, raw rhubarb, semen plantaginis, radix bupleuri, aired codonopsis pilosula, perillaseed, pericarpium zanthoxyli, liquorice, radix curcumae, fructus trichosanthis and aired Chinesedates. The brain-refreshing and mind-regulating ointment is a traditional Chinese medicine ointment which has better treatment effects than Western medicines, is safe and has no dependence and toxic or side effect; the brain-refreshing and mind-regulating ointment has the efficacies of quieting heart, calming nerves, soothing liver, strengthening spleen, regulating vital energy and blood circulation, nourishing heart and spleen, promoting blood circulation and removing blood stasis, particularly has remarkable effects to schizophrenia, depression disorders and anxiety disorders and is beneficial to the treatment of the diseases of insomnia, dizziness, headache and the like caused by hypertension.