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Application of radix angelicae pubescentis extract in preparation of medicine for treating and/or preventing atherosclerosis

A technology of atherosclerosis and extracts, which is applied in the field of new application of lovage extracts, to achieve the effects of inhibiting the occurrence and development, reducing the plaque area in the body, and improving the degree of vascular stenosis

Pending Publication Date: 2021-05-28
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether it has a therapeutic effect on coronary arteriosclerosis has not been reported yet.

Method used

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  • Application of radix angelicae pubescentis extract in preparation of medicine for treating and/or preventing atherosclerosis
  • Application of radix angelicae pubescentis extract in preparation of medicine for treating and/or preventing atherosclerosis
  • Application of radix angelicae pubescentis extract in preparation of medicine for treating and/or preventing atherosclerosis

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Experimental program
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preparation example Construction

[0037] The present application does not limit the preparation method of the lovage extract, as long as the purpose of the present invention can be achieved, for example, it can be obtained by ultrasonic extraction, microwave extraction, ethanol reflux extraction and other methods.

[0038] The second aspect of the present application provides the use of dihydro-aperegrol angelate in the preparation of medicaments for treating and / or preventing atherosclerosis.

[0039] The third aspect of the present application provides the use of imperatorin in the preparation of medicines for treating and / or preventing atherosclerosis.

[0040] The fourth aspect of the present application provides a pharmaceutical composition, which comprises at least one of dihydro-aperegrol angelate or imperatorin.

[0041] In some embodiments of the fourth aspect of the present application, the dihydro-aperegrol angelate is provided in the form of a monomer or in the form of a lovage extract.

[0042] I...

preparation example 1

[0123] Preparation Example 1 The preparation of the lovage extract

[0124] Weigh 10kg of Duhuo decoction pieces, put them in a round bottom flask, heat and reflux extraction with 95% ethanol and 60% ethanol respectively, the ratio of solid to liquid is 1:10, the extraction time is 2 hours each time, combine the two extracts, and filter. The extract was concentrated in a rotary evaporator, and dried under reduced pressure to obtain an extract of Rhododendron, and the yield of the extract by weighing was 14%. The obtained dried lovage extract is stored in a desiccator for future use.

[0125] The effect of dihydroparegrol angelate on AS

Embodiment 1 2

[0126] Example 1 Effect of Dihydro-Sapiol Angelic Acid Ester on AS Mice Aortic Plaque and Cardiac Aortic Sinus Lipid

[0127] Dosing method: the animal model of the present application is used for intragastric administration, wherein the administration group is divided into low dose group (1mg / ml dihydropapierol angelate, dosage 10ml / kg), middle dose group (2mg / ml dihydro-rapeol angelate, dosage 10ml / kg) and high-dose group (4mg / ml dihydro-raperol angelate, dosage 10ml / kg), every group of 12; The group was given 0.4mg / ml rosuvastatin, with a dosage of 10ml / kg; the model group and the control group were given 0.5% sodium carboxymethylcellulose with a dosage of 10ml / kg, and administered once a day by intragastric administration. 4 weeks. Four weeks later, the mice were killed, and blood and corresponding tissues were collected by the above-mentioned experimental method for biological experiments.

[0128] Aortic plaque is a very important evaluation index of atherosclerosis. T...

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Abstract

The embodiment of the invention provides application of the radix angelicae pubescentis extract in preparation of the medicine for treating and / or preventing the atherosclerosis, the columbianol angelica acid ester or imperatorin contained in the radix angelicae pubescentis extract has the effects of reducing the plaque area in a mouse with the atherosclerosis, and reducing the blood vessel stenosis degree. Effects of further inhibiting occurrence and development of plaques in ApoE- / - mice with high fat diet and like are realized. The obtained compound or the radix angelicae pubescentis extract containing the compound and the pharmaceutical composition can be expected to be used for treating and / or preventing atherosclerosis, and further can be used for preparing drugs for treating and / or preventing atherosclerosis.

Description

technical field [0001] The present invention relates to the technical field of new applications of lovage extracts, in particular to the use of lovage extracts in the preparation of medicines for treating and / or preventing atherosclerosis. Background technique [0002] Atherosclerosis (AS) is the main cause of cardiovascular disease, and its symptoms are usually discovered after complications such as myocardial infarction, stroke and peripheral arterial disease occur. Studies have shown that atherosclerosis is the result of lipid metabolism imbalance and continuous inflammatory response. A variety of genes and environmental factors lead to subcutaneous lipid deposition, foam cell formation, and immune cell infiltration in the vascular endothelium, and gradually form lipids protruding into the vascular lumen. Plaques eventually lead to stenosis and blockage of the lumen. Plaque rupture and thrombosis can eventually cause acute clinical cardiovascular and cerebrovascular even...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61K31/366A61P9/10A61K31/37
CPCA61K31/366A61P9/10A61K31/37
Inventor 常艳旭陈淑静李晋庞晓丽何俊王媛梁春晓
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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