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Confocal laser scanning microscope configured for generating line foci

A technology of line focus and focus, applied in the field of 3D optical imaging system, can solve the problem of 3D image data discomfort, patient data volume and other problems

Pending Publication Date: 2021-06-04
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, also in the present application, the long time required for the acquisition of 3D image data is unsuitable within a clinical workflow that has to deal with ever-increasing volumes of patient data.

Method used

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  • Confocal laser scanning microscope configured for generating line foci
  • Confocal laser scanning microscope configured for generating line foci
  • Confocal laser scanning microscope configured for generating line foci

Examples

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Embodiment Construction

[0083] figure 1 is a schematic diagram of the microscopic imaging system 1 according to the first exemplary embodiment. Microscopic imaging system 1 is configured such that probe light is detected using detector system 12 , wherein probe light is generated by object 4 in response to illumination light, which is generated by light source 2 and which is directed to object 4 . Probe light may include fluorescent and / or reflected illumination light.

[0084] The light source 2 may comprise a laser system such that the beam 3 of illumination light emitted from the light source 2 is a laser beam. However, it is also conceivable (in particular when combining Figure 6 In the third exemplary embodiment described), the light source 2 includes a non-laser light source, such as a halogen lamp. By way of example, the lasers may be configured as semiconductor diode lasers, gas or solid state lasers. The beam 3 of illumination light is directed to the object 4 using an optical system co...

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Abstract

The present disclosure relates to a microscopic imaging system for three-dimensional imaging. An optical system is provided for focusing illumination light generated by a light source to form a plurality of foci within an object. The optical system is further configured so that the foci, when seen relative to an optical axis of the optical system along which the illumination light is incident on the object, are mutually displaced from each other in an axial direction and mutually displaced from each other in a lateral direction. The optical system and / or a detector system are configured to compensate for the displacement along the axial direction so that for each of the foci, a light receiving portion of the detector system which receives a portion of the detection light is substantially located at a position which is optically conjugate to at least a portion of the respective focus.

Description

technical field [0001] The present invention relates to a three-dimensional optical imaging system configured to efficiently acquire three-dimensional images from an object using multiple line foci generated within the object. Background technique [0002] Many of today's biomedical research efforts center on the study of complex dynamic processes in cells, tissues and model organisms. These processes occur at different time scales. Considering the required spatial resolution for these studies, confocal laser scanning microscopy is a suitable technique as it allows highly resolved visualization of biological material. Confocal microscopy provides increased optical resolution and contrast of photomicrographs by means of spatial pinholes configured to block out-of-focus light. Typically, the pinhole is illuminated with reflected light or fluorescence emitted from the sample in response to being illuminated with a laser beam focused onto a fine spot within the sample. Raster...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B21/00G01N21/64G02B21/36
CPCG02B21/0032G02B21/0048G02B21/006G02B21/0076G02B21/008G02B21/367
Inventor S·斯托林加L·范德格拉夫
Owner KONINKLJIJKE PHILIPS NV