Application of deubiquitinating enzyme inhibitor in preparation of medicine for resisting rabies virus

A technology of deubiquitinase and rabies virus, applied in the field of medicine, can solve problems such as no related reports, and achieve important clinical value and application prospects.

Active Publication Date: 2021-06-11
ACAD OF MILITARY SCI PLA CHINA ACAD OF MILITARY MEDICAL SCI INST OF MILITARY VETERINARY MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no relevant report on the effect of PR-619 on rabies virus

Method used

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  • Application of deubiquitinating enzyme inhibitor in preparation of medicine for resisting rabies virus
  • Application of deubiquitinating enzyme inhibitor in preparation of medicine for resisting rabies virus
  • Application of deubiquitinating enzyme inhibitor in preparation of medicine for resisting rabies virus

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Embodiment Construction

[0028] The technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are part of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0029] Experimental Materials:

[0030] 1. Cells: BHK-21 cells (baby hamster kidney cells) were purchased from the Cell Bank of the Chinese Academy of Sciences and kept by the applicant's laboratory.

[0031] 2. Virus: rabies virus strain (CVS-11) (preserved in this experiment), stored at -80°C.

[0032] 3. Culture medium: MEM medium containing 5% (v / v) fetal bovine serum (FBS), with a final concentration of 100 U / mL penicillin and 100 μg / mL streptomycin.

[0033] 4. Drugs: Add 10 mg of 2,6-diamino-3,5-dithiocyanatopyr...

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Abstract

The invention provides application of a deubiquitinating enzyme inhibitor in preparation of a medicine for resisting rabies virus, and relates to the technical field of biological medicine. Experiments show that PR-619 has anti-rabies virus activity for the first time, and it is determined that PR-619 has prevention and treatment effects on rabies virus infection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the use of deubiquitinating enzyme inhibitors in the preparation of anti-rabies virus medicines. Background technique [0002] Rabies is a highly lethal zoonotic disease caused by rabies virus, which is characterized by invading the central nervous system and causing encephalitis in humans and other mammals. According to statistics, more than 60,000 people die from rabies every year in the world, and more than 15 million people receive post-exposure prophylaxis. Until now, rabies remains an incurable disease, and the only way to prevent it is through pre-exposure or post-exposure vaccination. Once clinical symptoms appear, the case fatality rate is as high as 100%. Therefore, the treatment of rabies is of great significance, and the research on finding anti-rabies virus drugs is imminent. [0003] PR-619 is a cell-permeable, broad, reversible deubiquitinating enzyme inhibitor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/44A61P31/14
CPCA61K31/44A61P31/14
Inventor 涂忠忠涂长春刘艳冯烨
Owner ACAD OF MILITARY SCI PLA CHINA ACAD OF MILITARY MEDICAL SCI INST OF MILITARY VETERINARY MEDICINE
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