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Application of deubiquitinating enzyme OTUD6A in preparation of medicine for preventing and treating prostatic cancer

A technology for deubiquitinating enzymes and prostate cancer, applied in the field of application in the preparation of drugs for the prevention and treatment of prostate cancer

Pending Publication Date: 2021-12-14
XI AN JIAOTONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the role of other OTU family proteins including OTUD6A in prostate cancer has not been reported

Method used

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  • Application of deubiquitinating enzyme OTUD6A in preparation of medicine for preventing and treating prostatic cancer
  • Application of deubiquitinating enzyme OTUD6A in preparation of medicine for preventing and treating prostatic cancer
  • Application of deubiquitinating enzyme OTUD6A in preparation of medicine for preventing and treating prostatic cancer

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Embodiment Construction

[0018] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments, which are explanations rather than limitations of the present invention.

[0019] The invention discloses the regulation mechanism of the deubiquitinating enzyme OTUD6A in prostate cancer and the application as a drug target.

[0020] The experimental means and experimental operation required by the invention are given below.

[0021] 1. Immunohistochemical analysis ( figure 1 A, 1B and image 3 D)

[0022] In human prostate tissue, human prostate tissue arrays were immunohistochemically stained with OTUD6A (ThermoFisher, PA5-62722, 1:500). The array included 66 cases of prostate cancer and 14 cases of normal paracancerous tissues.

[0023] In the mouse prostate tissue, the mouse prostate was taken and fixed with 4% paraformaldehyde. Fixed prostates were embedded in paraffin according to standard procedures, and 5 μm sections were subjected...

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Abstract

The invention discloses application of deubiquitinating enzyme OTUD6A in preparation of a medicine for preventing and treating prostatic cancer, and discloses the application of the deubiquitinating enzyme OTUD6A as a regulatory molecule of the prostatic cancer and application of the OTUD6A as a target in preparation of the medicine for treating the prostatic cancer. Specifically, the invention discloses expression change of the OTUD6A in a prostatic cancer patient, the regulation and control effect of the OTUD6A for the proliferation and energy metabolism process of prostatic cancer cells, and the regulation and control effect of the OTUD6A in a tumor formation process of the prostatic cancer cell. Therefore, the invention provides the application of the OTUD6A serving as a prostatic cancer molecular diagnosis marker and the application of the OTUD6A serving as the target in screening and preparation of medicines for treating and preventing the prostatic cancer.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of deubiquitinating enzyme OTUD6A as a prostate cancer regulatory molecule and the use of OTUD6A as a target in the preparation of drugs for preventing and treating prostate cancer. Background technique [0002] Tumor is one of the most important public health problems in the 21st century. According to the data released by the National Cancer Center of my country in 2017, the incidence rate of malignant tumors in China is 270.59 / 100,000, accounting for about 22% of the world; the mortality rate is 163.83 / 100,000, About 27% of the world. In China, new cases of prostate cancer accounted for 2.4% of male tumor cases, ranking seventh; death cases accounted for 1.47% of male death cases, ranking tenth. Although the overall incidence of prostate cancer in my country is not high, the incidence of prostate cancer The rate is increasing year by year, and has become the ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P35/00G01N33/574G01N33/573
CPCA61K45/00A61P35/00G01N33/57434G01N33/573
Inventor 龙建纲彭韵桦王珍祁红斌刘健康
Owner XI AN JIAOTONG UNIV
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