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Recombinant keratin liquid bandage and preparation method thereof

A liquid bandage and keratin technology, applied in bandages, medical science, etc., can solve the problems of complex waterproof and moisture-permeable processing technology, liquid bandages can’t fit wounds, secondary mechanical injuries, etc., to achieve rapid hemostasis wound healing, Effects of promoting mitosis and migration and avoiding secondary damage

Inactive Publication Date: 2021-06-18
海默斯(重庆)医学生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the defects in the prior art, the present invention provides a recombinant keratin liquid bandage and its preparation method, which solves the problem that the existing liquid bandage cannot fit well with the wound surface, and the liquid bandage is easily removed to cause secondary mechanical damage and waterproof. Technical problems such as performance and moisture permeability, complex processing technology, and poor product stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A recombinant keratin liquid bandage, 3 parts by mass, including 3 parts of recombinant corneum, 2 parts of glycerol, 1 NaCl 0.1, 1 nitrogen sodium, 13.4 parts of deionized water, ethyl acetate 40 copies of polyacrylate, 15 parts of aluminum powder, 8 parts of white mineral oil.

[0029] A method of preparing a recombinant keratin liquid bandage, comprising the steps of:

[0030] 1) The extracted recombinant angular oxese is added to deionized water, stirred for 20 min, then adding stabilizers and antibacterial agents, and stirring to uniformly obtain recombinant keratin solution;

[0031] 2) Adding a polymer film forming agent in an organic solvent for a high speed for 60 min, and then gradually adding an aluminum powder and white mineral oil to mix the mixed liquid after stirring while stirring.

[0032] 3) Mix the recombinant keratin solution to the mixed liquid to mix the recombinant keratin liquid bandage in the mixed liquid.

[0033] 4) Filter the recombinant keratin ...

Embodiment 2

[0035] A recombinant keratin liquid bandage, 4 parts by mass, including 4 parts of recombinant angle, 2.6 glycerol, NaCl 0.6 parts, sucrose 1. 0.1 parts, deionized water 15.4 parts, ethyl acetate 37 parts of, 5 parts of anhydrous ethanol, 20 polyacrylate, 18 parts of aluminum powder, 10 white mineral oils.

[0036] A method of preparing a recombinant keratin liquid bandage, comprising the steps of:

[0037] 1) Add the extracted recombinant keratin stock solution to deionized water, stirring for 22min, then adding stabilizers and antibacterial agents, continued to uniformly obtain recombinant keratin solution;

[0038] 2) When the polymer film forming agent is added to the organic solvent, the mixture is stirred at a high speed of 65min, and then the aluminum powder and white mineral oil are gradually added to the mixing to mix the mixed liquid after stirring.

[0039] 3) Mix the recombinant keratin liquid bandage in the mixed liquid in the mixed liquid to mix the recombinant kerat...

Embodiment 3

[0042]A recombinant keratin liquid bandage, according to the mass parts, including 4.4 parts of recombinant corneum, 2.8 parts of glycerol, 1.4 parts of NaCl, 1.4 parts of sucrose, 1.5.6 parts of deionized water, ethyl acetate 39 parts, 6 parts of anhydrous ethanol, 25 polyacrylates, 20 parts of aluminum powder, 11 parts of white mineral oil.

[0043] A method of preparing a recombinant keratin liquid bandage, comprising the steps of:

[0044] 1) Add the extracted recombinant keratinotrophy to deion water, stirring for 25 min, then adding stabilizers and antibacterial agents, and continues to be mixed to uniformly obtain recombinant keratin solution;

[0045] 2) Adding a polymer film forming agent in an organic solvent for high-speed stirring 70 min, and then gradually adding the aluminum powder and white mineral oil to mix the mixed liquid after stirring while stirring.

[0046] 3) Get a recombinant keratin liquid bandage in the mixed liquid in the mixed liquid in the mixed liqui...

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PUM

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Abstract

The invention relates to a recombinant keratin liquid bandage. The bandage comprises the following components of, in parts by mass, 20-30 parts of a recombinant keratin solution, 40-50 parts of an organic solvent, 18-32 parts of a polymer film-forming agent, 15-25 parts of aluminum powder and 8-14 parts of white mineral oil. After the liquid bandage is sprayed out, a layer of uniform macromolecular protective film can be formed on a wound and can be well attached to the wound, so that a compact physical barrier is formed, and the wound is prevented from being invaded by bacteria and microorganisms; the formed protective film is good in waterproofness and air permeability, and the recombinant keratin can promote migration and proliferation of cells, so that healing of the wound is accelerated; and the liquid bandage can keep a moisture degree for wound healing, so that secondary damage to the wound due to the fact that the wound is prone to be dried to form a scab is avoided, and the stability and practicability of the liquid bandage are good.

Description

Technical field [0001] The present invention relates to the field of liquid bandages, in particular, to a recombinant keratin liquid bandage and a preparation method thereof. Background technique [0002] Regardless of the size of the damage, the wound will cause the damage to the electrolyte balance in vivo. If the wound cannot be timely healing, it may cause the external bacterial invasion to make wound infections, and the wound infection will even lead to serious blood diseases such as sepsis; Nowadays, there have been a liquid bandage of various medical wounds at home and abroad; liquid bandages are substances consisting of film materials and solvents, which make wound heals by spraying the skin at the wound, but the current market There are some shortcomings in liquid bandages: 1) The existing liquid bandage cannot be bonded to the wound skin, which is easy to expose the damaged skin to the air, not only the role of rapid healing wounds, but it is easy to cause the wound bei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0047A61L26/0061A61L26/0004A61L26/0014C08L89/00C08L33/04
Inventor 查国栋余钡袁园
Owner 海默斯(重庆)医学生物技术有限公司
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