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Combination taxoid nanoemulsion with immunotherapy in cancer

一种纳米乳剂、紫杉的技术，应用在免疫球蛋白、药物组合、乳状液输送等方向，能够解决PDAC患者作用小等问题

Pending Publication Date: 2021-06-18
TARGAGENIX INC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite clinical success, these drugs work in only a small number of patients and have little effect in patients with PDAC

Method used

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  • Combination taxoid nanoemulsion with immunotherapy in cancer
  • Combination taxoid nanoemulsion with immunotherapy in cancer
  • Combination taxoid nanoemulsion with immunotherapy in cancer

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Experimental program
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Embodiment 1

[0064] Materials and methods

[0065] The docosahexaenoic acid conjugate of SBT-1214 (ie, DHA-SBT-1214) was synthesized by ChemMaster International, Inc. (Stony Brook, NY) according to a previously reported method. Extra pure omega-3 fish oil enriched fish oil was purchased from Jedwards International (Quincy, MA), Lipoid E80 (from Lipoid GMBH (Ludwigshafen, Germany)), DSPE PEG2000 (from Avanti Polar Lipids, Inc.) , Tween 80 (available from Sigma Chemicals, Inc. (St. Louis, MO)), Dulbecco's Modified Eagle Medium (DMEM) from Thermo Scientific (Rockford, IL) and LAL Chromogenic Endotoxin Quantification Kit. Penicillin, streptomycin and trypsin were purchased from Invitrogen (Grand Island, NY, USA). Female C57BL / 6 mice (4-6 weeks old) were purchased from Charles River Laboratories (Frederick Research Modeling Facility - NCI) (Cambridge, MA, USA). Amicon Ultra - 0.5ml centrifugal filter from Millipore (Cork, Ireland). All other analytical grade reagents were purchased through ...

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Abstract

A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nano emulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC, and a method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega-3 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer are disclosed.

Description

[0001] authorization information [0002] The research portion of this application was supported by grants from the National Institutes of Health (NIH grant numbers CA103314, CA132396, and HHSN261201500018C). The government has certain rights in this invention. technical field [0003] The present invention relates to the treatment of cancer, especially multidrug resistant cancer. More specifically, the present invention relates to combination therapy of paclitaxel and immunotherapy. Background technique [0004] PD-1 and PD-L1 inhibitors are immune checkpoint inhibitors used to treat various forms of cancer. Unfortunately, PD-L1 expression by tumor cells may be one of the important parameters related to, and possibly even required for, the efficacy of PD-1 / PD-L1 inhibitors, varying by tumor type and individual patient (see for example Taube et al. al., Clin Cancer Res; 20(19):5064-74 (2014) and Sunshine and Taube, Current Opinion in Pharmacology, 23:32-38 (2015)). CTLA-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/337A61K47/54A61K9/107A61K39/395A61P35/00A61P35/02
CPCA61K9/1075A61K31/337A61K39/39558A61K47/542A61P35/00A61P35/02A61K2039/505A61K2300/00C07K16/2827A61K47/44
Inventor J·E·伊根M·安米吉I·小岛
Owner TARGAGENIX INC
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