Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Treatment of chronic traumatic encephalopathy

A chronic trauma, traumatic technology, applied in the direction of organic active ingredients, non-central analgesics, medical preparations containing active ingredients, etc., can solve problems such as unclear TBI

Pending Publication Date: 2021-06-18
CTEC LLC
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is unclear how TBI leads to the development of hyperphosphorylated tau and progression to CTE

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Treatment of chronic traumatic encephalopathy
  • Treatment of chronic traumatic encephalopathy
  • Treatment of chronic traumatic encephalopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Human brain specimens were collected from the entorhinal cortex of athletes diagnosed with postmortem CTE. Specimens were stained for markers of ER stress alone and also colocalized with markers of tauopathies. Traditional immunohistochemistry was used in combination with primary antibodies specific for ER stress and pathological tau and fluorescent secondary antibodies. Overlapping regions were detected with colocalization software (ie, ImageJ). ANOVA was used to correct for total cytofluorescence analysis. P<0.05 was considered statistically significant. (*=p<0.05, **=p<0.01, and **=p<0.001).

[0073]The results showed that all three branches of the ER stress pathway were increased in human CTE specimens. ER stress was also found to be increased in the same regions where tauopathies were observed, suggesting ER stress during the disease process. This was confirmed by staining for glycogen synthase kinase β, GSK3β (a catalytic tau kinase associated with ER stress)...

Embodiment 2

[0078] This example evaluates the successful targeting of ER stress after TBI. Such as Figure 4 As shown in images A and B, a tabletop air acceleration damage model was developed. Sprague Dawley rats were placed in a protective tube to prevent damage to surrounding organs, and an acceleration wave was generated and collided with the rat's skull. The intensity of the damage was modulated in a stepwise manner by decreasing or increasing the thickness of the membrane exploded with pressurized nitrogen. An injury paradigm of 50 PSI was chosen, which correlates with human concussion, the most common type of injury associated with CTE. exist Figure 4 , the peak in plot D shows a 50 PSI pressure wave. Sprague Dawley rats received one or six injuries over a two-week period. Various time points of sacrifice were chosen to observe markers of ER stress and tauopathies.

[0079] Salubrinal was administered to rats after injury to target ER stress. Salubrinal was administered at a...

Embodiment 3

[0088] In this example, the effect of targeting (turning off) ER stress on improving behavior was investigated by using an injury model and standard protocols for the Morris water maze and the elevated plus maze. The Morris water maze detected deficits in cognitive performance, while the elevated plus maze assessed impulsive-like behavior. The results suggest that targeted ER stress can reduce impulsive-like behavior and improve cognitive performance if delivered after injury. Statistical analysis was performed using ANOVA, where *=p<0.05, **=p<0.01, ****=p<0.001. #=p<0.05, ##=p<0.01, ###=p<0.001 when drug was compared to the injury group.

[0089] Figure 11 Shown are images and plots illustrating that post-injury administration of salubrinal (SAL+bTBI) 7 days after a single injury reduces impulsive-like behavior as measured by reduced time in the open arm of the elevated plus maze. Plot A shows less time in open legs, such as trips.

[0090] Figure 12 Shown are images ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to compounds, compositions and methods to effectively treat traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE). As a result of administering a therapeutically effective amount of 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino) thioxomethyl] amino] ethyl]-2-propenamide and / or guanabenz, the effects of traumatic brain injury are mitigated and / or the development of chronic traumatic encephalopathy is reduced or precluded.

Description

[0001] Cross References to Related Applications [0002] Pursuant to 35 U.S.C. §119(e), this patent application claims priority benefit to U.S. Provisional Application No. 62 / 695,989, filed July 10, 2018, entitled "Treatment of Chronic Traumatic Encephalopathy," the contents of which are adopted This reference is hereby incorporated. technical field [0003] The present invention relates to the treatment of chronic traumatic encephalopathy (CTE), and more particularly to stabilizing, resolving or excluding the development of CTE (and more particularly CTE in patients with traumatic brain injury (TBI)) and / or or advanced compounds, compositions and methods. Background technique [0004] Traumatic brain injury (TBI) poses a serious health burden, affecting more than 30 million Americans each year. Even a subtle, potentially harmless mild TBI, which is the most common form of TBI, can have long-term consequences and lead to significant medical costs. Until recently, the mech...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47C07D215/40
CPCA61P29/00A61K9/0019A61K9/2004A61K31/4706A61K31/155A61K45/06A61P43/00A61K31/47A61K9/20
Inventor B·拉克-沃尔德R·图尔纳A·罗格斯顿
Owner CTEC LLC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com