Application of flavonoid compound and medicine for preventing ulcerative colitis

A flavonoid compound, a technology for ulcerative colitis, applied in the field of medicine, can solve the problems of difficult to cure or prevent the recurrence of inflammation, difficult to cure ulcerative colitis, endanger the health of patients, etc., to prevent and treat ulcerative colitis, Mortality reduction, effect of high bioavailability

Pending Publication Date: 2021-06-22
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Time of occurrence
[0004] Ulcerative colitis is difficult to cure, and there are few specific drugs for this disease. There are currently three types of conventional drugs for the treatment of ulcerative colitis in clinical practice: aminosalicylic acids, steroid glucocorticoids, and immunosuppressants. The effects of these drugs are all Not ideal, and side effects
Aminosalicylic acid drugs and corticosteroids are currently the main methods for the treatment of ulcerative colitis, but these non-specific anti-inflammatory and immunosuppressive drugs can only temporarily control and relieve symptoms, and it is difficult to completely cure or prevent the recurrence of inflammation. Fundamentally cure the disease, long-term use of adverse reactions increases, easy to relapse after drug withdrawal (1-year recurrence rate is greater than 50%), some hormone resistance or resistance intractable patients, the effect is not ideal, seriously endangering the health of patients

Method used

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  • Application of flavonoid compound and medicine for preventing ulcerative colitis
  • Application of flavonoid compound and medicine for preventing ulcerative colitis
  • Application of flavonoid compound and medicine for preventing ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The embodiment of the present application provides the construction of DSS group and LA+DSS group test, including:

[0042] Ten C57BL / 6 experimental animal mice of SPF grade male mice aged 6-8 weeks were randomly divided into two groups, which were marked as DSS group and LA+DSS group, respectively. figure 2 The schematic diagram of the feeding process for constructing the mouse model provided by the embodiment of the application, such as figure 2Shown, DSS group is to let mice drink the DSS aqueous solution that contains 3% (W / V) every day in 0~7 days, let mice drink normal water every day in 8~10 days, simultaneously, in 0~10 days, drink water every day 100 μl of drinking water (negative control) in the stomach induces ulcerative colitis in mice; the LA+DSS group allows the mice to drink the DSS aqueous solution containing 3% (W / V) in 0 to 7 days, and allows the mice to drink in 8 to 10 days Rats drank normal water, and at the same time, 100 μl of aqueous solution ...

Embodiment 2

[0044] The embodiment of the present application provides the determination of body weight change, mortality rate, colon length, disease activity index (DAI) score and H&E staining test after the flavonoid compound of formula I acts on the DSS model, including:

[0045] From 0 to 10 days, the pathological characteristics (body weight change, feces viscosity, and blood in stool) of the mice in the DSS group and the mice in the LA+DSS group were recorded every day, and the DAI scoring was performed. The DAI scoring is shown in Table 1.

[0046] Table 1

[0047] scoring system for disease activity index (DAI) disease activity index scoring system

[0048]

[0049] Observe and record the death status of the mice, and analyze the death rate of the two groups of mice by drawing.

[0050] Mouse colon lengths were measured after sacrifice on day 11.

[0051] Histopathological scoring (total score 0-20) was performed based on parameters such as inflammation, epithelial damage, cry...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to application of a flavonoid compound and a medicine for preventing ulcerative colitis. On the first aspect, the invention discloses application of the flavonoid compound in preparation of a medicine for preventing ulcerative colitis; on the second aspect, the invention discloses application of the flavonoid compound in preparation of a medicine for treating ulcerative colitis, and the flavonoid compound has a structure as shown in a formula I; and on the third aspect, the invention discloses a medicine for preventing ulcerative colitis, and the medicine comprises a flavonoid compound with the structure shown in the formula I and pharmaceutically acceptable auxiliary materials. The invention provides application of the flavonoid compound and a medicine for preventing ulcerative colitis, and aims at solving the technical defects that in the prior art, medicines for preventing and treating ulcerative colitis are poor in specificity and large in side effect.

Description

technical field [0001] The application belongs to the technical field of medicine, and in particular relates to the application of a flavonoid compound and a preventive medicine for ulcerative colitis. Background technique [0002] Ulcerative colitis is an inflammatory bowel disease. It is a chronic non-specific autoimmune disease of unknown cause, which is related to various factors such as genetics, immunity, infection, and environment. Abdominal pain and tenesmus, etc. The main pathological features are chronic inflammation and ulceration of the colonic mucosa, which cannot be cured. It is the same as Crohn's disease as two typical inflammatory bowel diseases. The incidence of ulcerative colitis in my country is also increasing year by year. The disease is difficult to cure, and it is often easy to relapse after recovery. It has been listed as one of the modern refractory diseases by the World Health Organization. [0003] Existing technologies mainly focus on acute ent...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K36/258A61P1/04A61P1/00
CPCA61K31/7048A61K36/258A61P1/04A61P1/00
Inventor 黄俊卿夏希纯陈家旭张莹莹马庆宇郝闻致祝乐清
Owner JINAN UNIVERSITY
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