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Collagenase inhibitor, repair cream containing collagenase inhibitor and preparation method of repair cream

A collagenase and inhibitor technology, applied in the field of cosmetics, can solve the problems of high molecular weight of hydrolyzed collagen and difficulty reaching the dermis, and achieve the effect of excellent inhibition, easy raw materials and simple operation

Pending Publication Date: 2021-07-16
GUANGZHOU KENENG COSMETICS RES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the existing technology, the molecular weight of hydrolyzed collagen is too large, and it is difficult to penetrate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; peptides and retinol have certain irritation and safety risks to the skin etc., the present invention firstly provides a collagenase inhibitor and a preparation method thereof

Method used

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  • Collagenase inhibitor, repair cream containing collagenase inhibitor and preparation method of repair cream
  • Collagenase inhibitor, repair cream containing collagenase inhibitor and preparation method of repair cream
  • Collagenase inhibitor, repair cream containing collagenase inhibitor and preparation method of repair cream

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preparation example Construction

[0043]The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and may be a common method in the art, specifically including the step of mixing the components of the collagenase inhibitor. For example, the ginseng extract and the Sophora flavescens root extract are uniformly mixed in a conventional mixing manner.

[0044] Collagenase

[0045] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinase, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (Extra-Cellar Matrix, ECM). The main function of collagenase is to degrade collagen and elastin in the dermis, and its tissue inhibitors (Tissue Inhibitors of Metalloproteinase, TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site , jointly regulate matrix metabolism and main...

Embodiment

[0099] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0100] Ginseng extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.;

[0101] Sophora flavescens root extract was purchased from: Beijing Baililaisi Biochemical Co., Ltd.

Embodiment 1-5

[0107] Ginseng extract and Sophora flavescens root extract are provided as collagenase inhibitors. Ginseng extract and Sophora flavescens root extract are by mass ratio 1:2 (embodiment 1), 1:1 (embodiment 2), 5:1 (embodiment 3), 15:1 (embodiment 4), 20 : 1 (embodiment 5) after mixing, obtain collagenase inhibitor.

[0108] The collagenase inhibitor of Example 1 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0109] The collagenase inhibitors of Example 2 were dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0110] The collagenase inhibitor of Example 3 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0111] The collagenase inhibitor of Example 4 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions, the concentrations of which were 640 μg / mL, 480 μg / mL, 320 μg / mL, 160 μg / mL, 80 ...

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Abstract

The invention provides a collagenase inhibitor, a repair cream containing the collagenase inhibitor and a preparation method of the repair cream. The collagenase inhibitor comprises a ginseng extract and a radix sophorae flavescentis root extract, and based on the total mass of the collagenase inhibitor, the addition amount of the ginseng extract is 51-97%, and the addition amount of the radix sophorae flavescentis root extract is 3-49%. The collagenase inhibitor of the present invention has an excellent inhibiting effect on the activity of collagenase, and has no side effects on the human body.

Description

technical field [0001] The invention relates to a collagenase inhibitor, a repair cream containing the collagenase inhibitor and a preparation method thereof, belonging to the field of cosmetics. Background technique [0002] Collagen is mainly produced by fibroblasts in the dermis and is the main component of the dermis. It can maintain the structure of the skin and give the skin toughness and elasticity. The content and distribution of collagen determine the youthfulness of the skin. However, the abnormal reduction of collagen content will cause the thinning of the dermis, loose skin, loss of elasticity, and wrinkles, which will affect people's quality of life. With the deepening of research on collagen, researchers have found that collagenase plays an important role in the homeostasis of skin collagen, and its overexpression and abnormal activation are one of the main causes of skin aging. Therefore, inhibiting the activity of collagenase can block the degradation of sk...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/34A61Q19/08
CPCA61K8/9789A61K8/345A61Q19/08A61K2800/782
Inventor 杨登亮谢佩佩张伟杰李传茂张楚标曾伟丹
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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