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Application of miR-129 in preparation of product for treating depression

A mir-129, depression technology, applied in the field of biomedicine, can solve problems such as poorly understood functions, and achieve the effect of improving depression symptoms and good application prospects

Active Publication Date: 2021-07-20
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are effective treatments for depression, less than half of patients worldwide (less than 10% in some countries) receive effective treatment
Current research on the function of miR-129 mainly focuses on the regulation of tumorigenesis and development, and its role in other biological processes is still poorly understood

Method used

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  • Application of miR-129 in preparation of product for treating depression
  • Application of miR-129 in preparation of product for treating depression
  • Application of miR-129 in preparation of product for treating depression

Examples

Experimental program
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Effect test

Embodiment 1

[0053] 1. Animal materials

[0054] SPF-grade male C57BL / 6 mice, products of Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., aged 8-10 weeks, with an average weight of 21-25g, were raised in the Academy of Military Medical Sciences, No. 27, Taiping Road Experimental Animal Center. The mice were kept in a good environment, with standard mouse food, clean drinking water, free diet, relative temperature at 20-24°C, relative humidity at 55%±15%, light rhythm of 12 hours in bright field and dark field in 12 hours, and illumination at 280-350 LX. All animal experiments were performed in accordance with the "Guide for the Care and Use of Laboratory Animals" approved by the Academy of Military Medical Sciences. All experimental protocols were approved by the Institutional Institutional Review Board for Animal Experiments.

[0055] 2. Construction of depression model mice

[0056] 1. Construction of depression model mice

[0057] Eight-week-old C57BL / 6 mice were ran...

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Abstract

The invention discloses an application of miR-129 in preparation of a product for treating depression. It is found in the invention that the depressive symptom of a mouse can be obviously improved by inner side habenular nucleus overexpression of the miR-129 of a depression mouse model, which indicates that the miR-129 or a substance for regulating and controlling the content or expression quantity of the miR-129 can be used for treating depression. Therefore, the micromolecule miR-129 can be used as a novel antidepressant drug, a safe and durable antidepressant effect can be achieved by single injection in an inner side habenular nucleus area, and the micromolecule miR-129 has a good clinical application prospect.

Description

technical field [0001] The invention relates to the application of miR-129 in the preparation of products for treating depression in the field of biomedicine. Background technique [0002] As one of the most serious mental illnesses affecting human life, depression has a high incidence rate. There are more than 300 million depressed patients in the world, and the incidence rate is as high as 11%. The incidence rate of depression in my country is 3.02%. Major Depressive Disorder (MDD) affects about 16% of the population and is an important cause of disability. MDD is characterized by depressed mood, listlessness, difficulty concentrating, and increased suicidal tendencies. At its worst, depression can lead to suicide. Suicide deaths are estimated to be as high as 1 million people each year. Although effective treatments for depression exist, less than half of patients worldwide (less than 10% in some countries) receive effective treatment. Antidepressant drugs widely used...

Claims

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Application Information

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IPC IPC(8): A61K31/7088A61K45/00A61P25/24C12N15/864C12N5/10
CPCA61K31/7088A61K45/00A61P25/24C12N15/86C12N5/0622C12N2750/14143C12N2800/107C12N2510/00
Inventor 江小霞王妍王常勇王长振张鹤扬秦巧臻刘水蓉徐振华
Owner ACADEMY OF MILITARY MEDICAL SCI
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