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Application of compound gymnadenia conopsea pills in preparation of medicine for treating depression

A technology for depression and postpartum depression, which is applied in the field of medicine and can solve the problems of undiscovered reports or studies on the treatment of depression with Compound Shoushen Pills

Inactive Publication Date: 2017-03-01
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report or research on the use of Compound Shoushen Pill or other preparations of its formula for the treatment of depression in the prior art

Method used

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  • Application of compound gymnadenia conopsea pills in preparation of medicine for treating depression
  • Application of compound gymnadenia conopsea pills in preparation of medicine for treating depression
  • Application of compound gymnadenia conopsea pills in preparation of medicine for treating depression

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0018] Experimental example 1. Improvement effect on forced swimming and tail suspension disappointed depression model mice

[0019] 1. Experiment preparation

[0020] Male Kunming mice, body weight (20±2) g, license number: SCXK (Lu) 2008-0002, provided by Shandong Lukang Pharmaceutical Co., Ltd. Compound Shoushen Pills (Jinhe Tibetan Medicine Co., Ltd., batch number 20140511). Positive control drug fluoxetine hydrochloride dispersible tablets (Eli Lilly Suzhou Pharmaceutical Co., Ltd., batch number: 2842A, specification: 20 mg). Electronic balance (AL104), Mettler-Toledo Instrument (Shanghai) Co., Ltd., rotary evaporator (RE-52C), Shanghai Qingpu Huxi Instrument Factory.

[0021] 2. Experimental method

[0022] 1. Grouping and dosage

[0023] The mice were randomly grouped according to body weight, 10 in every group, divided into blank group (given same volume of distilled water); positive drug group (fluoxetine hydrochloride group 20mg / kg); and 1000mg / kg administration...

experiment example 2

[0038] Experimental example 2. Clinical research on the treatment of postpartum depression with Fufang Shoushen Pills

[0039] 1. Patient data and diagnostic criteria

[0040] 1. General information:

[0041] 52 patients with postpartum depression, aged 23 to 48 years, with an average age of 33.1 years; 29 cases of cesarean section, 23 cases of natural delivery; 40 cases of primipara, 12 cases of multipara. They were randomly divided into treatment group Ⅰ (18 cases), treatment group Ⅱ (17 cases) and control group 17 cases. There was no significant difference (P>0.05) among the three groups in terms of age, mode of delivery, and number of deliveries (P>0.05), and they were comparable.

[0042] 2. Diagnostic criteria:

[0043] According to the diagnostic criteria in "Chinese Classification and Diagnostic Criteria for Mental Disorders" (CCMD-3) and "Diagnostic and Statistical Manual of Mental Disorders" (DSM-IV). Depression occurs within 2 weeks after delivery, and there are ...

experiment example 3

[0087] Experimental Example 3: Clinical Study of Compound Shoushen Pills in Treating Climacteric Depression

[0088] 1. Patient data and diagnostic criteria

[0089] 1. General information:

[0090] There were 49 menopausal depression patients, aged 52-68 years, with an average age of 59.1 years; 22 males and 27 females. They were randomly divided into a treatment group of 25 cases and a control group of 24 cases. There was no significant difference in age, sex, and HAMD score between the two groups (P>0.05), which were comparable.

[0091] 2. Diagnostic criteria:

[0092] According to the diagnostic criteria in "Chinese Classification and Diagnostic Criteria for Mental Disorders" (CCMD-3) and "Diagnostic and Statistical Manual of Mental Disorders" (DSM-IV). The course of disease lasts at least 2 weeks, and the HAMD-17 score is greater than 17 points. All patients excluded encephalopathy, no history of genetic psychiatry and acquired psychiatric history.

[0093] 2. Metho...

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Abstract

The invention discloses application of compound gymnadenia conopsea pills in preparation of a medicine for treating depression so as to overcome technology biases of technology application in the prior art. It is found through animal experiments that the compound gymnadenia conopsea pills help to obviously shorten motionless time of mice in forced swimming and tail-suspension disappointment and depression model experiments and have the same effects as positive drugs. It is found through clinical researches that the compound gymnadenia conopsea pills, separately or used along with fluoxertine hydrochloride, can remarkably improve symptoms of depression and substantially reduce HAMD value, have the same effects as fluoxertine hydrochloride when separately used, and have more excellent effects if used along with fluoxertine hydrochloride.

Description

technical field [0001] The invention relates to the application of compound Shoushen pills in the preparation of medicines for treating depression, and belongs to the field of medicine. Background technique [0002] Depression, also known as depressive disorder, is often seen clinically with low mood, slow thinking, decreased active speech, slow behavior, passive life, unwilling to interact with others, easy to shed tears and cry, and some cases have obvious anxiety and motor agitation, severe Patients may experience psychotic symptoms such as hallucinations and delusions. With the acceleration of the pace of life and the increase of life and work pressure, depression has become a common disease affecting human health. It is a disease with high morbidity, disability and mortality, which seriously endangers people's physical and mental health. Therefore, depression has become a research hotspot in the field of medicine today. The common ones are postpartum depression, senil...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/20A61P25/24A61K31/137A61K31/4525
Inventor 邵成雷付素心赵丽丽王红月田小雪
Owner SHANDONG JINHE DRUG RES DEV
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