Atypical antipsychotic medicinal composition

An antipsychotic drug and atypical technology, applied in the field of medicine, can solve the problems of patients with residual negative symptoms, reduce patient compliance, poor social function, etc., so as to reduce medical costs, improve compliance, and reduce the incidence of serious toxic and side effects. Effect
CN108926569AInactive Publication Date: 2018-12-04FIRST HOSPITAL OF SHANXI MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FIRST HOSPITAL OF SHANXI MEDICAL UNIV
Publication Date
2018-12-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an atypical antipsychotic medicinal composition. The medicinal composition contains active components risperidone and sertraline hydrochloride according to a weight ratio of 0.04:1 to 0.08:1, and is applied to the treatment of SCZ when the dosage of risperidone in the active components is 2-4 mg / d. Low-dosage risperidone and sertraline hydrochloride in the medicinal composition have excellent synergistic effects; and compared with medium and high dosage risperidone, the medicinal composition has the advantages of equivalent positive symptom elimination effect, significant elimination of negative symptoms and emotion symptoms, and improvement of the social function of SCZ patients when used in the treatment of SCZ. The medicinal composition greatly reduces the occurrence probability of medium and high dosage risperidone induced hyperprolactinemia, severe extrapyramidal symptoms and other adverse drug events.
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Description

technical field

[0001] The invention belongs to the technical field of medicine and relates to a pharmaceutical composition, in particular to an antipsychotic pharmaceutical composition, which can effectively treat schizophrenia with a low dose of the pharmaceutical composition of the invention. Background technique

[0002] Schizophrenia (SCZ) is a chronic severe mental illness with high recurrence rate, high disability rate, high mortality rate and high disease burden, which is extremely harmful to human health, and its etiology is unknown so far. 1%.

[0003] The main symptoms of SCZ include positive symptoms, negative symptoms, affective symptoms and cognitive symptoms. Positive symptoms mainly include hallucinations, delusions, disorganized speech and behavior, nervous or agitated behavior; negative symptoms mainly include emotional bluntness or incoordination, reduced social interaction, withdrawn and withdrawn, lack of speech and interest, decreased willpower, lazy l...

Claims

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