Establishment method and application of animal model with nerve injury induced by HIV infection

A nerve injury, animal model technology, applied in the field of biomedicine, can solve the problem of not acquiring HIV-1 infection, unable to faithfully simulate the initial infection stage or AIDS progression, etc.
CN113143974AActive Publication Date: 2021-07-23WUHAN UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WUHAN UNIV OF SCI & TECH
Publication Date
2021-07-23

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Abstract

The invention relates to an establishment method and application of an animal model with nerve injury induced by HIV infection. The establishment method comprises a chimeric HIV virus inoculated in the abdominal cavity of a mouse or a chimeric HIV virus injected in the caudal vein of the mouse after the mouse is anesthetized by isoflurane, wherein the chimeric HIV virus has a nucleotide sequence as shown in SEQID NO.1. The animal model can greatly promote mechanism studying on nerve injury of patients caused by HIV, and can be used for pharmaceutical effect determination and pharmacological studying of anti-HIV related nerve injury medicines, especially has a great application value in the aspect of screening of new drugs.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a method for establishing an animal model of nerve injury caused by HIV infection and its application. Background technique

[0002] Although combined antiretroviral therapy (cART) can systematically inhibit HIV virus replication and maintain a very low viral load, most cART drugs cannot cross the blood-brain barrier, causing HIV-related neuropathy. Cognitive impairment (HAND) is still prevalent. With the prolongation of patient survival, about 50% of infected patients will further develop into HIV-associated neurocognitive disorders (HAND), including psychomotor slowing, attention, memory, Motor function, executive function, verbal fluency, information processing speed, sensory / perception. The evolution of HAND is from preclinical asymptomatic neurocognitive impairment (asymptomatic neurocognitive impairment, ANI) to mild neurocognitive disorder (mild neurocogn...

Claims

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