Chitosan arginine gel dressing for repairing dental tubules

A saccharinine gel and dental tubule technology, applied in dentistry, dental preparations, dental prostheses, etc., can solve the problem of slow relief of dentin hypersensitivity pain, low dentinal tubule sealing effect, and poor periodontal reconstruction effect, etc. To reduce dentin hypersensitivity, improve uniform sealing and stable adhesion, and promote repair

Active Publication Date: 2021-08-13
绽妍生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the treatment of dentin hypersensitivity, desensitization care drugs are usually used. Although it can relieve the pain of dentin hypersensitivity and play a certain role in blocking the dental tubules, it often has a slow relief speed for dentin hypersensitivity pain. Moreover, the sealing effect on dentinal tubules is low, the adhesion with tooth tissue is small, the effect of dentinal tub

Method used

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  • Chitosan arginine gel dressing for repairing dental tubules
  • Chitosan arginine gel dressing for repairing dental tubules
  • Chitosan arginine gel dressing for repairing dental tubules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1-can be used for the chitosan arginine gel dressing of dental tubule restoration, according to the ratio of parts by weight, including 2 parts of bioactive glass, 0.1 part of functional mixture, 1 part of sorbitol, 2 parts of carbomer, 0.5 part of glycerin 3 parts, 3 parts of hydroxyethyl cellulose and 20 parts of water.

[0029] The preparation method of this chitosan arginine gel dressing comprises:

[0030] (1) Preparation of modified β-chitosan: After adding dopamine to 50°C hot water to completely dissolve it, adjust the pH to 8.0 with a concentration of 1mol / L sodium hydroxide solution, stir for 1 hour in a light-proof airtight container, and let stand 5h; add citric acid to adjust the pH to 6.5, add β-chitosan with 2.5 times the mass of dopamine, fully stir at a constant temperature of 35°C for 0.8h, and perform ultrasonic treatment for 30s to obtain modified β-chitosan;

[0031] (2) Preparation of functional mixture: add modified β-chitosan and argi...

Embodiment 2

[0033] Embodiment 2-the chitosan arginine gel dressing that can be used for dental tubule restoration, it differs from embodiment 1 in that it also includes 0.1 parts by weight of gamma polyglutamic acid.

[0034] The preparation method of this chitosan arginine gel dressing,

[0035] (1) Preparation of modified β-chitosan: After adding dopamine to 50°C hot water to completely dissolve it, adjust the pH to 8.0 with a concentration of 1mol / L sodium hydroxide solution, stir for 1 hour in a light-proof airtight container, and let stand 5h; add citric acid to adjust the pH to 6.5, add β-chitosan with 2.5 times the mass of dopamine, fully stir at a constant temperature of 35°C for 0.8h, and perform ultrasonic treatment for 30s to obtain modified β-chitosan;

[0036] (2) Preparation of functional mixture: add modified β-chitosan and arginine to 55% of the water according to the mass ratio of 1:6, and stir until completely dissolved to obtain the functional mixture;

[0037] (3) Mix...

Embodiment 3

[0039] Embodiment 3-can be used for the chitosan arginine gel dressing of dental tubule repair, according to the ratio of parts by weight, including 3 parts of bioactive glass, 0.4 part of functional mixture, 0.2 part of gamma polyglutamic acid, 5 parts of sorbitol , 3 parts of carbomer, 1 part of glycerin, 6 parts of hydroxyethyl cellulose and 25 parts of water.

[0040] The preparation method of this chitosan arginine gel dressing,

[0041] (1) Preparation of modified β-chitosan: After dopamine is completely dissolved in hot water at 60°C, adjust the pH to 8.5 with 1mol / L sodium hydroxide solution, stir in a light-proof airtight container for 2 hours, and let it stand 7h; add citric acid to adjust the pH to 6.8, add β-chitosan with 3.2 times the mass of dopamine, fully stir at a constant temperature of 40°C for 1.2h, and perform ultrasonic treatment for 60s to obtain modified β-chitosan;

[0042] (2) Preparation of functional mixture: add modified β-chitosan and arginine to...

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Abstract

The invention provides a chitosan arginine gel dressing for repairing dental tubules. The chitosan arginine gel dressing comprises 0.1-0.4 part by weight of a functional mixture, wherein the functional mixture is prepared by mixing modified beta-chitosan and arginine according to a mass ratio of (1-3): (6-8), and the modified beta-chitosan is obtained by compounding and modifying catechol and beta-chitosan under a weak acid condition. The chitosan arginine gel dressing prepared by the invention can better accelerate a sealing effect on dentin tubules, can quickly relieve dentin allergic aching pain, quickly resist allergy and strengthen teeth, has high sealing effect on the dentin tubules, and is beneficial to enhancing anti-inflammatory, tooth-strengthening and desensitization effects of the dentin.

Description

technical field [0001] The invention relates to the technical field of oral dressings, in particular to a chitosan arginine gel dressing which can be used for tooth tubule restoration. Background technique [0002] Dentin is the bone-like material of the tooth, covered by enamel above the gum line and cementum below the gum line. Dentin tubules are tubular structures that run through the entire layer of dentin, also known as dentinal tubules. When the enamel and cementum are destroyed due to various reasons, when the dental tubules are exposed in the oral cavity, the permeability of the dentin will increase, bacteria and other stimuli will enter the dentin to form bacterial colonization, and the bonding performance of the restoration will decrease. question. Therefore, the opening of dental tubules is an important cause of dentin hypersensitivity. Therefore, how to scientifically and effectively seal and repair dental tubules, reduce the occurrence of dentin hypersensitivi...

Claims

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Application Information

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IPC IPC(8): A61K6/898A61K6/891A61K6/60A61K6/69A61K6/836
CPCA61K6/898A61K6/891A61K6/60A61K6/69A61K6/836C08L5/08C08L1/284C08L77/04
Inventor 祖月榕
Owner 绽妍生物科技有限公司
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