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Corydalis saxicola suppository for treating and/or preventing pelvic inflammation and preparation method thereof

A technology for pelvic inflammatory disease and Coptis chinensis suppository is applied in the field of preparation of traditional Chinese medicine suppositories, and achieves the effects of significant drug effect, less interference, and reduced toxicity and side effects

Active Publication Date: 2021-08-27
肖萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

How to make Yanhuanglian traditional Chinese medicine into a suppository with stable and efficient dissolution rate and good product properties, there is no relevant report so far

Method used

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  • Corydalis saxicola suppository for treating and/or preventing pelvic inflammation and preparation method thereof
  • Corydalis saxicola suppository for treating and/or preventing pelvic inflammation and preparation method thereof
  • Corydalis saxicola suppository for treating and/or preventing pelvic inflammation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A kind of rhizomes suppository for treating and preventing pelvic inflammatory disease, whose raw materials are weighed according to the following weight:

[0045] Litectin extract (calculated as dehydrocarvitin) 8.0g

[0046] 38# mixed fatty acid glyceride 990g

[0047] 36# mixed fatty acid glyceride 495g

[0048] Tween 80 172g

[0049] 7.8g borneol

[0050] Lanolin 29g

[0051] Light liquid paraffin 29g

[0052] Sodium Lauryl Sulfate 2.4g

[0053] Prepare 1000 capsules, the preparation method is as follows:

[0054] The preparation of the extract of Litectin: take the medicinal material of Litectin, cut it into sections, add 70% ethanol solvent for soaking for 45min, heat and reflux extraction with 9 times the weight of ethanol solvent of Litectin, the number of times of reflux extraction is 2 times, each time For 50 minutes, the two extracts were combined and concentrated under reduced pressure until there was no alcohol smell, and the ethanol was recovered to...

Embodiment 2

[0060] A kind of rhizomes suppository for treating and preventing pelvic inflammatory disease, whose raw materials are weighed according to the following weight:

[0061] Litectin extract (calculated as dehydrocarvitin) 8.25g

[0062] 38# mixed fatty acid glyceride 1000.0g

[0063] 36# mixed fatty acid glyceride 500.0g

[0064] Tween 80 174.5g

[0065] borneol 8.0g

[0066] Lanolin 30g

[0067] Light liquid paraffin 30g

[0068] Sodium lauryl sulfate 2.5g.

[0069] Prepare 1000 capsules, the preparation method is as follows:

[0070] The preparation of the extract of Litectin: take the medicinal material of Litectin, cut it into sections, add 75% ethanol solvent for soaking for 60 minutes, heat and reflux extraction with 10 times the weight of ethanol solvent of Litectin, the number of times of reflux extraction is 2 times, each time After 60 minutes, the two extracts were combined and concentrated under reduced pressure until there was no alcohol smell, and the ethanol...

Embodiment 3

[0076] A kind of rhizomes suppository for treating and preventing pelvic inflammatory disease, whose raw materials are weighed according to the following weight:

[0077] Litectin extract (calculated as dehydrocarvitin) 8.0-8.5g

[0078] 38# mixed fatty acid glyceride 990-1008g

[0079] 36# mixed fatty acid glyceride 495-504g

[0080] Tween 80 172-175g

[0081] Borneol 7.8-8.2g

[0082] Lanolin 29-31g

[0083] Light liquid paraffin 29-31g

[0084] Sodium lauryl sulfate 2.4-2.6g.

[0085] Prepare 1000 capsules, the preparation method is as follows:

[0086] The preparation of the extract of Litectin: take the medicinal material of Litectin, cut into sections, add 80% ethanol solvent for soaking for 70 minutes, heat and reflux extraction with 12 times the weight of ethanol solvent of Litectin, the number of times of reflux extraction is 2 times, each time For 70 minutes, the two extracts were combined and concentrated under reduced pressure until there was no alcohol smel...

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Abstract

The invention provides a corydalis saxicola suppository for treating and / or preventing pelvic inflammation and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine suppository preparation. The corydalis saxicola suppository is prepared from the following raw materials in parts by weight: 8.0 to 8.5 parts of corydalis saxicola extract (based on dehydrocavidine), 990 to 1008 parts of 38# mixed fatty glyceride, 495 to 504 parts of 36# mixed fatty glyceride, 172 to 175 parts of Tween 80, 7.8 to 8.2 parts of borneol, 29 to 31 parts of wool fat, 29 to 31 parts of light liquid paraffin, and 2.4 to 2.6 parts of lauryl sodium sulfate. The corydalis saxicola suppository provided by the invention has the advantages of higher dissolution rate, stable dissolution performance, remarkable drug effect and good appearance and storage stability.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicine suppositories, in particular to a Yanhuanglian suppository for treating and preventing pelvic inflammatory disease and a preparation method thereof. Background technique [0002] Pelvic inflammatory disease (PID) is a common clinical disease and frequently-occurring disease, which belongs to upper reproductive tract infection, including endometritis, salpingitis, tubal-ovarian abscess, pelvic connective tissue inflammation and pelvic peritonitis. Pelvic inflammatory disease is the disease name of western medicine. There is no disease name of pelvic inflammatory disease in ancient Chinese medicine books. According to its clinical manifestations, it can be attributed to traditional Chinese medicine "women's abdominal pain", "mass in the abdomen", "heat entering the blood chamber", and "leukorrhagia". and other categories. It is the only disease for which Chinese ...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/02A61K47/06A61K47/10A61K47/14A61K47/20A61K47/26A61K47/44A61P15/00A61P29/00
CPCA61K36/66A61K9/02A61K47/14A61K9/0034A61K47/10A61K47/26A61K47/06A61K47/44A61K47/20A61P15/00A61P29/00A61K2236/333A61K2236/39A61K2236/53A61K2236/51
Inventor 肖萍曾定元诸葛明丽林彩霞
Owner 肖萍
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