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Continuous crystallization method of etimicin sulfate

A technology of etimicin and etimicin sulfate, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of cumbersome process and low yield, and achieve high-quality raw materials and products The effect of high yield and uniform distribution of crystal grains

Inactive Publication Date: 2021-09-03
WUXI JIMIN KEXIN SHANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to overcome the problems of low yield and cumbersome process, to propose innovation and provide a

Method used

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  • Continuous crystallization method of etimicin sulfate

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Effect test

Embodiment 1

[0034] Such as figure 1 A continuous crystallizer shown, it includes a cooling crystallization system and a circulation constant temperature condensation system,

[0035] Wherein: the cooling crystallization system includes a feeding tank, a crystallization tank and a preparatory tank for ensuring that the feed is adjusted to pH, the crystallization stock solution is communicated with the liquid inlet of the preparatory tank through a pipeline, and the liquid outlet of the preparatory tank is connected with the crystallization tank 3 through a pipeline. The first liquid inlet provided on the top is connected, and the side wall of the crystallization tank is provided with an interlayer; the middle part of the crystallization tank is provided with a guide tube in the vertical direction, between the inner wall of the crystallization tank and the outer wall of the guide tube and is located in the crystallization tank. A baffle is set in the supernatant liquid area of ​​the tank, t...

Embodiment 2

[0041] A process for continuous crystallization in a continuous crystallizer, comprising the following steps:

[0042] (1), the etimicin hydrolyzate enters the preparatory tank through the pipeline, and sulfuric acid is added dropwise under stirring, until the final pH of the mother liquor is 4.0, and the temperature is controlled at 20°C;

[0043] (2) Pass a constant temperature liquid into the interlayer of the side wall of the crystallizer to raise the temperature in the crystallizer until the temperature in the crystallizer is the same as that of the feed material, and the crystallization stock solution is pumped into the crystallizer from the first liquid inlet through the feed pump In the device; open the feeding tank, wherein the feeding tank contains methanol or ethanol with a concentration between 30% and 100%, the liquid in the clear liquid area of ​​the crystallizer is passed into the feeding tank through the pipeline, and then passed into the crystallization through...

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Abstract

The invention relates to a crystallization method of etimicin sulfate. The method comprises the following steps: a) purifying reaction hydrolysate containing etimicin sulfate, which is obtained in the last step of preparing etimicin sulfate, through a continuous crystallization process; and b) after dissolving, obtaining high-purity etimicin sulfate by using a membrane concentration method.

Description

technical field [0001] The invention relates to a production technology of aminoglycoside antibiotics, in particular to a continuous crystallization process of aminoglycoside antibiotic etimicin sulfate. Background technique [0002] Etimicin sulfate (Etimicin sulfate) is a new generation of semi-prepared aminoglycoside antibiotics with high efficiency, low toxicity and resistance to drug-resistant bacteria with independent intellectual property rights. It is the only one that has obtained the national first-class new drug certificate. Anti-infective drugs. Its mechanism of action is to resist the normal protein production of sensitive bacteria, and it is effective against Escherichia coli, Klebsiella pneumoniae, Enterobacter spp. etc. have high antibacterial activity, have certain antibacterial activity to some Pseudomonas, Acinetobacter, etc. The MIC values ​​of Helicobacter and Klebsiella pneumoniae are still within the plasma concentration range of the therapeutic dose...

Claims

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Application Information

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IPC IPC(8): C07H1/06C07H15/236
CPCC07H1/06C07H15/236
Inventor 姜迎庆王彬於江华尤岚
Owner WUXI JIMIN KEXIN SHANHE PHARMA
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